S. Diane Hayward
Johns Hopkins University School of Medicine
71 Papers
955 Citations
S. Diane Hayward is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Epstein–Barr virus & Virus. The author has an hindex of 41, co-authored 71 publications. Previous affiliations of S. Diane Hayward include Johns Hopkins University & University of California, Los Angeles.
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Papers
S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding
Makoto R. Hara,Nishant Agrawal,Sangwon F. Kim,Matthew B. Cascio,Masahiro Fujimuro,Yuji Ozeki,Masaaki Takahashi,Jaime H. Cheah,Stephanie Tankou,Lynda D. Hester,Christopher D. Ferris,S. Diane Hayward,Solomon H. Snyder,Akira Sawa +13 more
TL;DR: A signalling pathway in which nitric oxide generation that follows apoptotic stimulation elicits S-nitrosylation of GAPDH, which triggers binding to Siah1 (an E3 ubiquitin ligase), nuclear translocation and apoptosis, which is prevented by NO deletion is reported.
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Sequence-specific DNA binding of the Epstein-Barr virus nuclear antigen (EBNA-1) to clustered sites in the plasmid maintenance region
TL;DR: The demonstration of sequence-specific binding at multiple loci suggests that EBNA-1 has pleiotropic functions, which may include control of copy number and segregation of the EBV plasmids as well as initiation of replication.
528
A novel viral mechanism for dysregulation of β-catenin in Kaposi's sarcoma–associated herpesvirus latency
Masahiro Fujimuro,Frederick Y. Wu,Colette Aprhys,Henry Kajumbula,David B. Young,Gary S. Hayward,S. Diane Hayward +6 more
TL;DR: The Kaposi's sarcoma–associated herpesvirus (KSHV) latency-associated nuclear antigen (LANA) is expressed in all KSHV-associated tumors, and it is found that β-catenin is overexpressed in both PEL cells and KS tissue.
324
SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function.
Sifang Zhou,Masahiro Fujimuro,James J. Hsieh,Lin Chen,Alison Miyamoto,Gerry Weinmaster,S. Diane Hayward +6 more
TL;DR: The results suggest a model in which NotchIC activates responsive promoters by competing with the SMRT-corepressor complex for contacts on both CBF1 and SKIP.
276
Protein Interactions Targeting the Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus to Cell Chromosomes
TL;DR: The data indicate that the latency-associated nuclear antigen is tethered to chromosomes through two independent chromatin binding domains that interact with different protein partners.
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