S. Braghi
University of Milan
12 Papers
175 Citations
S. Braghi is an academic researcher from University of Milan. The author has contributed to research in topics: Autoantibody & Islet. The author has an hindex of 10, co-authored 12 publications. Previous affiliations of S. Braghi include Vita-Salute San Raffaele University.
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Papers
Modulation of humoral islet autoimmunity by pancreas allotransplantation influences allograft outcome in patients with type 1 diabetes.
TL;DR: A minority of patients receiving pancreas allografts under generalized immunosuppression show a stimulation of islet autoantibody reactivity characteristic of that found in preclinical type 1 diabetes, which is almost invariably followed by graft function failure and resumption of insulin therapy.
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Fresh human islet transplantation to replace pancreatic endocrine function in type 1 diabetic patients. Report of six cases.
C. Socci,L. Falqui,A. M. Davalli,Camillo Ricordi,S. Braghi,Federico Bertuzzi,P. Maffi,Antonio Secchi,F. Gavazzi,M. Freschi,P. Magistretti,S. Socci,A. Vignali,V. Di Carlo,Guido Pozza +14 more
TL;DR: Results show that an adequate number of human islets injected intraportally in type 1 diabetic patients can replace the pancreatic endocrine function and can lead to insulin independence.
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Autoantibodies to glutamic acid decarboxylase (GAD) detected by an immuno-trapping enzyme activity assay: Relation to insulin-dependent diabetes mellitus and islet cell antibodies
Gianvito Martino,Marcel Tappaz,S. Braghi,Nicoletta Dozio,Nicola Canal,Guido Pozza,Gian Franco Bottazzo,Luigi M.E. Grimaldi,Emanuele Bosi +8 more
TL;DR: This study indicates that GAD-Ab measured by ITEAA are detected in a proportion of IDDM patients; strongly associated with ICA; preferentially found in IDDM female patients with autoimmune polyendocrine serology; and detected with lower frequency than that reported for 64K-Ab in ID DM.
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•Journal Article
Selection of donors significantly improves pig islet isolation yield.
Carlo Socci,Camillo Ricordi,Alberto M. Davalli,Carlo Staudacher,P. Baro,A. Vertova,Massimo Freschi,F. Gavazzi,S. Braghi,Guido Pozza,V. Di Carlo +10 more
TL;DR: In this paper, a modification of the automated method for human islet isolation was used for pig islet separation, after ductal injection of a collagenase solution (Seromed, type C-1000) the islets were separated through a continuous digestion process.
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Human islets chronically exposed in vitro to different stimuli become unresponsive to the same stimuli given acutely: evidence supporting specific desensitization rather than beta-cell exhaustion.
Alberto M. Davalli,Antonio E. Pontiroli,Carlo Socci,Federico Bertuzzi,B. Fattor,S. Braghi,V. Di Carlo,Guido Pozza +7 more
TL;DR: The finding of a preserved insulin content in the islets after perifusions and a maintained capability to release insulin in response to supramaximal stimulations suggest that after chronic exposure to different stimuli, human islets become selectively desensitized to the same stimuli given acutely and do not become exhausted.
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