S. Alfonso
Sapienza University of Rome
16 Papers
101 Citations
S. Alfonso is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Mycobacterium tuberculosis & Antimycobacterial. The author has an hindex of 12, co-authored 15 publications. Previous affiliations of S. Alfonso include GlaxoSmithKline & Harvard University.
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Papers
MmpL3 Is the Cellular Target of the Antitubercular Pyrrole Derivative BM212
Valentina La Rosa,Giovanna Poce,Julio Ortiz Canseco,Silvia Buroni,Maria Rosalia Pasca,Mariangela Biava,Ravikiran M. Raju,Giulio Cesare Porretta,S. Alfonso,Claudio Battilocchio,Babak Javid,Flavia Sorrentino,Thomas R. Ioerger,James C. Sacchettini,Fabrizio Manetti,Maurizio Botta,Alessandro De Logu,Eric J. Rubin,Edda De Rossi +18 more
TL;DR: The screening of genomic libraries and whole-genome sequencing found that all the characterized mutants showed mutations in the mmpL3 gene, allowing us to conclude that resistance to BM212 maps to the MMPL3 protein, a member of the MmpL (mycobacterial membrane protein, large) family.
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Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection.
Giovanna Poce,Robert H. Bates,S. Alfonso,Martina Cocozza,Giulio Cesare Porretta,Lluis Ballell,Joaquín Rullas,Fátima Ortega,Alessandro De Logu,E Agus,Valentina La Rosa,Maria Rosalia Pasca,Edda De Rossi,Baojie Wae,Scott G. Franzblau,Fabrizio Manetti,Maurizio Botta,Mariangela Biava +17 more
TL;DR: In vitro and in vivo target validation evidence presented here adds further weight to MmpL3 as a druggable target of interest for anti-tubercular drug discovery.
A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity.
Claudio Battilocchio,Giovanna Poce,S. Alfonso,Giulio Cesare Porretta,Sara Consalvi,Lidia Sautebin,Simona Pace,Antonietta Rossi,Carla Ghelardini,Lorenzo Di Cesare Mannelli,Silvia Schenone,Antonio Giordani,Luigia Di Francesco,Paola Patrignani,Mariangela Biava +14 more
TL;DR: Compound 1c proved to be extremely effective in vivo, showing an interesting anti-nociceptic profile that is comparable to reference compounds already marketed, hence representing a great stimulus for a further improvement of this class of molecules.
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Identification of a novel pyrrole derivative endowed with antimycobacterial activity and protection index comparable to that of the current antitubercular drugs streptomycin and rifampin.
Mariangela Biava,Giulio Cesare Porretta,Giovanna Poce,Claudio Battilocchio,S. Alfonso,Alessandro De Logu,Nadia Serra,Fabrizio Manetti,Maurizio Botta +8 more
TL;DR: Antitubercular activity and protection index of the new compound are comparable to those found for the current antitubercular drugs streptomycin and rifampin.
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Novel Analgesic/Anti-Inflammatory Agents: Diarylpyrrole Acetic Esters Endowed with Nitric Oxide Releasing Properties
Mariangela Biava,Giulio Cesare Porretta,Giovanna Poce,Claudio Battilocchio,S. Alfonso,Michele Rovini,Salvatore Valenti,Gianluca Giorgi,Calderone,Alma Martelli,Lara Testai,L. Sautebin,Antonietta Rossi,Papa G,Carla Ghelardini,Di Cesare Mannelli L,Antonio Giordani,Paola Anzellotti,Annalisa Bruno,P. Patrignani,Anzini M +20 more
TL;DR: A new class of pyrrole-derived nitrooxy esters (11a-j), cyclooxygenase-2 (COX-2) selective inhibitors endowed with NO releasing properties, with the goal of generating new molecules able to both strongly inhibit this isoform and reduce the related adverse side effects.
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