Ryuichi Watanabe
Keio University
18 Papers
130 Citations
Ryuichi Watanabe is an academic researcher from Keio University. The author has contributed to research in topics: Osteoclast & Bone resorption. The author has an hindex of 12, co-authored 18 publications.
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Papers
Smad2/3 Proteins Are Required for Immobilization-induced Skeletal Muscle Atrophy
Toshimi Tando,Akiyoshi Hirayama,Mitsuru Furukawa,Yuiko Sato,Tami Kobayashi,Atsushi Funayama,Arihiko Kanaji,Wu Hao,Ryuichi Watanabe,Mayu Morita,Takatsugu Oike,Kana Miyamoto,Tomoyoshi Soga,Masatoshi Nomura,Akihiko Yoshimura,Masaru Tomita,Morio Matsumoto,Masaya Nakamura,Yoshiaki Toyama,Takeshi Miyamoto +19 more
TL;DR: It is shown that skeletal muscle immobilization elevates Smad2/3 protein but not mRNA levels in muscle, promoting atrophy, and myostatin, which negatively regulates muscle hypertrophy, is dispensable for denervation-induced muscle atrophy and Smad 2/3protein accumulation.
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Elevation of pro-inflammatory cytokine levels following anti-resorptive drug treatment is required for osteonecrosis development in infectious osteomyelitis.
Mayu Morita,Ryotaro Iwasaki,Yuiko Sato,Tami Kobayashi,Ryuichi Watanabe,Takatsugu Oike,Satoshi Nakamura,Yosuke Keneko,Kana Miyamoto,Kazuyuki Ishihara,Yoichiro Iwakura,Ken Ishii,Morio Matsumoto,Masaya Nakamura,Hiromasa Kawana,Taneaki Nakagawa,Takeshi Miyamoto +16 more
TL;DR: Administration of anti-resorptive agents such as the bisphosphonate alendronate accelerates osteonecrosis promoted by infectious osteomyelitis, and demonstrates that TNFα-, IL-1α/β- or IL-6-deficient mice as well as wild-type mice administered a TNFβ-inhibitor were significantly resistant to development of oste onecrosis accompanying infectious myelitis.
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Methotrexate inhibits osteoclastogenesis by decreasing RANKL‑induced calcium influx into osteoclast progenitors
Hiroya Kanagawa,Ritsuko Masuyama,Mayu Morita,Yuiko Sato,Yasuo Niki,Tami Kobayashi,Eri Katsuyama,Atsuhiro Fujie,Wu Hao,Toshimi Tando,Ryuichi Watanabe,Kana Miyamoto,Hideo Morioka,Morio Matsumoto,Yoshiaki Toyama,Hideyuki Saya,Takeshi Miyamoto +16 more
TL;DR: Osteoclast formation and expression of osteoclastic genes such as NFATc1 and DC-STAMP, which are induced by the cytokine RANKL, are significantly inhibited by methotrexate (MTX), and it was found that RankL-dependent calcium (Ca) influx into osteoclast progenitors was significantly inhibition by MTX.
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A serum metabolomics-based profile in low bone mineral density postmenopausal women
Takeshi Miyamoto,Akiyoshi Hirayama,Yuiko Sato,Tami Koboyashi,Eri Katsuyama,Hiroya Kanagawa,Hiroya Miyamoto,Tomoaki Mori,Shigeyuki Yoshida,Atsuhiro Fujie,Mayu Morita,Ryuichi Watanabe,Toshimi Tando,Kana Miyamoto,Takashi Tsuji,Atsushi Funayama,Masaya Nakamura,Morio Matsumoto,Tomoyoshi Soga,Masaru Tomita,Yoshiaki Toyama +20 more
TL;DR: These findings represent novel metabolomic profiling in low BMD in postmenopausal women with or without low bone mineral density (low BMD vs controls) for the first time using capillary electrophoresis/mass spectrometry.
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Metabolomics-based profiles predictive of low bone mass in menopausal women.
Takeshi Miyamoto,Akiyoshi Hirayama,Yuiko Sato,Tami Koboyashi,Eri Katsuyama,Hiroya Kanagawa,Atsuhiro Fujie,Mayu Morita,Ryuichi Watanabe,Toshimi Tando,Kana Miyamoto,Takashi Tsuji,Atsushi Funayama,Tomoyoshi Soga,Masaru Tomita,Masaya Nakamura,Morio Matsumoto +16 more
TL;DR: The data shows metabolomics changes represent useful markers to predict estrogen deficiency and/or bone loss in women grouped as pre-menopausal with normal bone mineral density (BMD), post- menopausal withnormal BMD (low estrogen and normal BMD; LN), or post-Menopausal with low BMD( low estrogen and low B MD; LL) using comprehensive metabolomics analysis.
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