Ryosuke Ishimura
Niigata University
13 Papers
3 Citations
Ryosuke Ishimura is an academic researcher from Niigata University. The author has contributed to research in topics: Endoplasmic reticulum & Autophagy. The author has an hindex of 7, co-authored 10 publications. Previous affiliations of Ryosuke Ishimura include Juntendo University & Institute of Medical Science.
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Papers
Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.
Yoshinobu Ichimura,Satoshi Waguri,Yu-shin Sou,Shun Kageyama,Jun Hasegawa,Ryosuke Ishimura,Tetsuya Saito,Yinjie Yang,Tsuguka Kouno,Toshiaki Fukutomi,Takayuki Hoshii,Atsushi Hirao,Kenji Takagi,Tsunehiro Mizushima,Hozumi Motohashi,Myung-Shik Lee,Tamotsu Yoshimori,Keiji Tanaka,Masayuki Yamamoto,Masaaki Komatsu +19 more
TL;DR: It is shown that phosphorylation of the autophagy-adaptor protein p62 markedly increases p62's binding affinity for Keap1, an adaptor of the Cul3-ubiquitin E3 ligase complex responsible for degrading Nrf2, and that inhibitors of the interaction between phosphorylated p62 and Keap 1 have potential as therapeutic agents against human HCC.
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Biallelic UFM1 and UFC1 mutations expand the essential role of ufmylation in brain development
Michael S. Nahorski,Sateesh Maddirevula,Ryosuke Ishimura,Saud Alsahli,Angela F. Brady,Anaïs Begemann,Tsunehiro Mizushima,Francisco J. Guzmán-Vega,Miki Obata,Yoshinobu Ichimura,Hessa S. Alsaif,Shams Anazi,Niema Ibrahim,Firdous Abdulwahab,Mais Hashem,Dorota Monies,Mohamed Abouelhoda,Brian F. Meyer,Majid Alfadhel,Wafa Eyaid,Markus Zweier,Katharina Steindl,Anita Rauch,Stefan T. Arold,C. Geoffrey Woods,Masaaki Komatsu,Fowzan S. Alkuraya,Fowzan S. Alkuraya +27 more
TL;DR: In this article, the authors established a locus for severe early-onset encephalopathy with progressive microcephaly based on two families, and map the phenotype to a novel homozygous UFM1 mutation.
96
Biallelic Variants in UBA5 Link Dysfunctional UFM1 Ubiquitin-like Modifier Pathway to Severe Infantile-Onset Encephalopathy.
Mikko Muona,Ryosuke Ishimura,Ryosuke Ishimura,Anni Laari,Yoshinobu Ichimura,Tarja Linnankivi,Riikka Keski-Filppula,Riikka Keski-Filppula,Riitta Herva,Heikki Rantala,Heikki Rantala,Anders Paetau,Minna Pöyhönen,Miki Obata,Takefumi Uemura,Thomas Karhu,Norihisa Bizen,Hirohide Takebayashi,Shane McKee,Michael Parker,Nadia Akawi,Jeremy F. McRae,Matthew E. Hurles,Outi Kuismin,Outi Kuismin,Mitja I. Kurki,Anna-Kaisa Anttonen,Keiji Tanaka,Aarno Palotie,Satoshi Waguri,Anna-Elina Lehesjoki,Masaaki Komatsu +31 more
TL;DR: Exome sequencing in Finnish individuals with severe epileptic syndromes and cellular analyses imply that the combination of a hypomorphic p.Ala371Thr variant in trans with a loss-of-function allele in UBA5 underlies a severe infantile-onset encephalopathy, suggesting that the UFM1 system is essential for CNS development and function.
92
Dissection of the role of p62/Sqstm1 in activation of Nrf2 during xenophagy.
TL;DR: It is shown that translocation of p62/Sqstm1 to invasive Salmonella precedes Ser351 phosphorylation, which means that cytoprotective Nrf2 targets are induced at the same time that autophagosomes entrap the microbes (xenophagy).
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Novel therapeutic strategy for cervical cancer harboring FGFR3-TACC3 fusions.
Ryo Tamura,Kosuke Yoshihara,Tetsuya Saito,Ryosuke Ishimura,Juan Emmanuel Martinez-Ledesma,Hu Xin,Tatsuya Ishiguro,Yutaro Mori,Kaoru Yamawaki,Kazuaki Suda,Seiya Sato,Hiroaki Itamochi,Teiichi Motoyama,Yoichi Aoki,Shujiro Okuda,Cristine R Casingal,Hirofumi Nakaoka,Ituro Inoue,Roel G.W. Verhaak,Masaaki Komatsu,Takayuki Enomoto +20 more
- 23 Jan 2018
TL;DR: RNA sequencing data from 306 cervical cancer samples identified four samples that harbored FGFR3-TACC3 fusion as an attractive therapeutic target and revealed that an IL8-triggered inflammatory response was increased, via activation ofFGFR3–MAPK signaling.