Ryea Maswood
UCL Institute of Ophthalmology
12 Papers
3 Citations
Ryea Maswood is an academic researcher from UCL Institute of Ophthalmology. The author has contributed to research in topics: Retina & Neurodegeneration. The author has an hindex of 6, co-authored 10 publications. Previous affiliations of Ryea Maswood include University College London.
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Papers
Differentiation and Transplantation of Embryonic Stem Cell-Derived Cone Photoreceptors into a Mouse Model of End-Stage Retinal Degeneration
Kamil Kruczek,Anai Gonzalez-Cordero,Debbie Goh,Arifa Naeem,Mindaugas Jonikas,Samuel J.I. Blackford,Magdalena Kloc,Yanai Duran,Anastasios Georgiadis,Robert D. Sampson,Ryea Maswood,Alexander J. Smith,Sarah Decembrini,Yvan Arsenijevic,Jane C. Sowden,Rachael A. Pearson,Emma L. West,Robin R. Ali,Robin R. Ali +18 more
TL;DR: It is established that stage-specific inhibition of the Notch pathway increases cone cell differentiation, while retinoic acid signaling regulates cone maturation, comparable with their actions in vivo.
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Gene Therapy for Glaucoma by Ciliary Body Aquaporin 1 Disruption Using CRISPR-Cas9
Jiahui Wu,Jiahui Wu,Oliver Bell,David A. Copland,Alison Young,John R. Pooley,Ryea Maswood,Rachel S Evans,Peng T. Khaw,Robin R. Ali,Andrew D. Dick,Andrew D. Dick,Colin J Chu +12 more
TL;DR: Clinical translation of this approach to patients with glaucoma may permit long-term reduction of IOP following a single injection.
71
Gene Therapy Targeting the Inner Retina Rescues the Retinal Phenotype in a Mouse Model of CLN3 Batten Disease
Sophia-Martha Kleine Holthaus,Mikel Aristorena,Ryea Maswood,Olha Semenyuk,Justin Hoke,Aura Hare,Alexander J. Smith,Sara E. Mole,Sara E. Mole,Robin R. Ali,Robin R. Ali +10 more
TL;DR: It is demonstrated that Cln3Δex7/8 mice, a mouse model of CLN3 Batten disease with juvenile onset, suffer from a decline in inner retinal function resulting from the death of rod bipolar cells, interneurons vital for signal transmission from photoreceptors to ganglion cells in the retina, which indicates that bipolar cells play a central role in this disease.
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Neonatal brain-directed gene therapy rescues a mouse model of neurodegenerative CLN6 Batten disease.
Sophia-Martha Kleine Holthaus,Saul Herranz-Martin,Saul Herranz-Martin,Giulia Massaro,Mikel Aristorena,Justin Hoke,Michael P. Hughes,Ryea Maswood,Olha Semenyuk,Mark Basche,Amna Z. Shah,Izabela P Klaska,Alexander J. Smith,Sara E. Mole,Sara E. Mole,Ahad A. Rahim,Robin R. Ali,Robin R. Ali +17 more
TL;DR: It is shown that neonatal bilateral intracerebroventricular injections with AAV9 carrying ClN6 increase lifespan by more than 90%, maintain motor skills and motor coordination and reduce neuropathological hallmarks of Cln6-deficient mice up to 23 months post vector administration, demonstrating that brain-directed gene therapy is a valid strategy to treat the neurodegeneration of CLN6 disease.
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Late neuroprogenitors contribute to normal retinal vascular development in a Hif2a-dependent manner
Enrico Cristante,Sidath E. Liyanage,Robert D. Sampson,Aikaterini A. Kalargyrou,Giulia De Rossi,Matteo Rizzi,Justin Hoke,Joana Ribeiro,Ryea Maswood,Yanai Duran,Takaaki Matsuki,Nozie D. Aghaizu,Ulrich F O Luhmann,Alexander J. Smith,Robin R. Ali,James W B Bainbridge +15 more
TL;DR: It is demonstrated in mouse that retinal neuroprogenitor cells interact intimately with the growing retinal vascular network, and a novel regulatory mechanism of vasculature development mediated by hypoxia-inducible factor 2a (Hif2a).