Ryan W. Nelson
University of Minnesota
11 Papers
13 Citations
Ryan W. Nelson is an academic researcher from University of Minnesota. The author has contributed to research in topics: T cell & Cytotoxic T cell. The author has an hindex of 6, co-authored 9 publications.
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Papers
Single Naive CD4+ T Cells from a Diverse Repertoire Produce Different Effector Cell Types during Infection
Noah J. Tubo,Antonio J. Pagán,Justin J. Taylor,Ryan W. Nelson,Jonathan L. Linehan,James M. Ertelt,Eric S. Huseby,Sing Sing Way,Marc K. Jenkins +8 more
TL;DR: The mechanism that underlies this division of labor by tracking the progeny of single naive T cells is studied, which results from averaging the diverse behaviors of individual clones, which are instructed in part by the strength of TCR signaling.
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Tolerance is established in polyclonal CD4(+) T cells by distinct mechanisms, according to self-peptide expression patterns.
Deepali Malhotra,Jonathan L. Linehan,Jonathan L. Linehan,Thamotharampillai Dileepan,You Jeong Lee,Whitney E. Purtha,Jennifer V Lu,Ryan W. Nelson,Brian T. Fife,Harry T. Orr,Mark S. Anderson,Kristin A. Hogquist,Marc K. Jenkins +12 more
TL;DR: The immunotolerance of polyclonal CD4+ T cells was maintained by distinct mechanisms, according to self-peptide expression patterns, according on the effects of specific expression patterns on the same epitope-specific T cells.
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T cell receptor cross-reactivity between similar foreign and self peptides influences naive cell population size and autoimmunity.
Ryan W. Nelson,Daniel Beisang,Noah J. Tubo,Thamotharampillai Dileepan,Darin L. Wiesner,Kirsten Nielsen,Marcel Wüthrich,Bruce S. Klein,Dmitri I. Kotov,Justin A. Spanier,Brian T. Fife,James J. Moon,Marc K. Jenkins +12 more
TL;DR: It is found that nonamer peptides that bind to the same MHCII molecule only need to share five amino acids to cross-react on the same TCR, which can reduce the size of certain foreign peptide-specific T cell populations and might allow Tcell populations specific for tissue-restricted self peptides to cause autoimmunity after infection.
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CD4+ T Cell Persistence and Function after Infection Are Maintained by Low-Level Peptide:MHC Class II Presentation
TL;DR: CD4+ memory–phenotype T cells decline over time when generated in response to acute infections cleared by other components of the immune system, so it was of interest to assess the stability of CD4+ T cells during a persistent Salmonella infection, which is typical of persistent phagocytic infections that are controlled by this lymphocyte subset.
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SARS-CoV-2 epitope-specific CD4+ memory T cell responses across COVID-19 disease severity and antibody durability
Ryan W. Nelson,Yuezhou Chen,Olivia L. Venezia,Richard Majerus,Daniel Shin,Mary Carrington,Duane R. Wesemann,James J. Moon,Andrew D. Luster,B. A. Abayneh,P. Allen,Galit Alter,Diane Antille,Katrina L Armstrong,Alejandro B. Balazs,Julia Bals,M. Barbash,Yannic C. Bartsch,Julie Boucau,Siobhan Boyce,Janet F. Braley,Karen Marie Coperich Branch,Katherine Broderick,J. Carney,Andrew T. Chan,Josh Chevalier,Fatema Z. Chowdhury,George Q. Daley,Susan P. Davidson,Michael Dougan,D. A. Drew,Kevin Einkauf,Ashley Elliman,Jonathan K. Fallon,Liz Fedirko,Kelsey K. Finn,Keith T. Flaherty,Jeanne Flannery,Pamela J. Forde,Pilar Garcia-Broncano,Elise Gettings,David E. Golan,Amanda J. Griffin,Sheila Grimmel,Kathleen A. Grinke,Kathryn T. Hall,Ciputra Adijaya Hartana,Michael D. Healy,H. Heller,Deborah Henault,Grace Holland,Chenyang Jiang,Nikolaus Jilg,Paulina Kaplonek,Marshall Karpell,Chantal Kayitesi,Evan C. Lam,V Roberto Lavalle,Kristina Lefteri,Xiao-Mei Lian,Mathias Lichterfeld,Daniel Lingwood,Huan Liu,Jinqing Liu,Yuting Lu,Sarah Luthern,N. Ly,J. Marchewka,Brittani Martino,R. McNamara,Ashlin R. Michell,Ilan Millstrom,Noah Miranda,Christian Nambu,S. Nelson,Marjorie Noone,Claire O'Callaghan,Christine Ommerborn,Matthew Osborn,Lois Chris Pacheco,Nicole Phan,Shiv Pillai,F. A. Porto,Yelizaveta Rassadkina,Alexandra Reissis,Alexandra Rosenthal,Francis Ruzicka,Edward Francis Ryan,Kyra Seiger,K. Selleck,Libera Sessa,Arlene H. Sharpe,Christianne Sharr,Sally Shin,Nishant K. Singh,Sue Slaughenhaupt,Kim Sheppard,Weiwei Sun,Xiaoming Sun,Elizabeth Suschana,Hannah J. Ticheli,Alicja Trocha-Piechocka,Vivine Wilson,Colline Wong,Daniel P Worrall,Alex Lee Zhu,Zachary Manickas-Hill,Edward Demers,Kelly Judge,Musie Ghebremichael,Peggy S Lai,Jonathan Z. Li,Bruce D. Walker,Maureen P. Martin,Yuko Yuki +114 more
TL;DR: Analysis of SARS-CoV-2-specific CD4+ T cells responses in a subset of individuals with sustained anti-S antibody responses following viral clearance also revealed an increased proportion of memory cTfh cells, indicating efficient early disease control also predicts favorable long-term adaptive immunity.
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