Ryan T. Mott
Wake Forest University
40 Papers
291 Citations
Ryan T. Mott is an academic researcher from Wake Forest University. The author has contributed to research in topics: Medicine & Temozolomide. The author has an hindex of 14, co-authored 37 publications. Previous affiliations of Ryan T. Mott include Duke University & Wake Forest Baptist Medical Center.
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Papers
Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD
Carol A. Colton,Ryan T. Mott,Hayley J. Sharpe,Qing Xu,William E. Van Nostrand,Michael P. Vitek +5 more
TL;DR: The findings confirmed that treatment of microglia with anti-inflammatory cytokines such as IL-4 and IL-13 induces a gene profile typical of alternative activation similar to that previously observed in peripheral macrophages and suggest that innate immune cells in AD may exhibit a hybrid activation state that includes characteristics of classical and alternative activation.
Comprehensive Genomic Profiling of 282 Pediatric Low- and High-Grade Gliomas Reveals Genomic Drivers, Tumor Mutational Burden, and Hypermutation Signatures
Adrienne Johnson,Eric Allan Severson,Jo-Anne Vergilio,Julia A. Elvin,James Suh,Sugganth Daniel,Mandy Covert,Garrett M. Frampton,Sigmund Hsu,Glenn J. Lesser,Kimberly Stogner-Underwood,Ryan T. Mott,Sarah Rush,Jennifer Stanke,Sonika Dahiya,James Sun,Prasanth Reddy,Zachary R. Chalmers,Rachel L. Erlich,Yakov Chudnovsky,David Fabrizio,Alexa B. Schrock,Siraj M. Ali,Vincent A. Miller,Philip J. Stephens,Jeffrey S. Ross,John R. Crawford,Shakti H. Ramkissoon +27 more
TL;DR: The most common alterations across diagnosis and anatomic location are explored and tumor mutational burden and associated genetic factors that may predispose patients to developing a hypermutator phenotype are discussed.
254
Neuronal expression of CD22: novel mechanism for inhibiting microglial proinflammatory cytokine production.
Ryan T. Mott,Ghania Ait-Ghezala,Terrence Town,Takashi Mori,Martina Vendrame,Jin Zeng,Jared Ehrhart,Michael Mullan,Jun Tan +8 more
TL;DR: It is demonstrated, using neuron‐microglial cocultures, that neurons are capable of inhibiting LPS‐induced tumor necrosis factor‐α (TNF‐α) production by microglia, and that neurons secrete CD22, which functions as an inhibitor of microglial proinflammatory cytokine production.
176
MR Enterography in the Management of Patients with Crohn Disease
John R. Leyendecker,Richard S. Bloomfeld,David J. DiSantis,Gregory S Waters,Ryan T. Mott,Robert E. Bechtold +5 more
TL;DR: Although MR enterography currently is helpful for management in individual patients, the standardization of acquisition protocols and interpretive methods would increase its usefulness for more rigorous, systematic assessments of Crohn disease treatment regimens.
145
Merkel cell carcinoma: a clinicopathologic study with prognostic implications.
TL;DR: This study examined 25 cases of MCC with an attempt to identify clinical, histopathological, or immunohistochemical features capable of predicting disease outcome.
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