Ryan M. Murphy

TL;DR: It is shown that CRISPR-Bac can be used to knock down proteins of interest, to create targeted genetic deletions with high efficiency, and to activate or repress transcription of protein-coding genes and an imprinted long noncoding RNA.

TL;DR: This work investigates the expression and function of NRAS depalmitoylating acyl protein thioesterases 1 and 2 and concludes that palmostatin B has effects on NRAS downstream signaling and cell viability in NRAS mutant melanoma cells, offering an interesting starting point for future studies.

TL;DR: It is found that LH2 overexpression dramatically increases HNSCC cell migratory and invasive abilities in vitro and that LH 2-driven changes in collagen cross-linking robustly induces metastasis in vivo, implicate LH2 as a key regulator of H NSCC tumor invasion and metastasis by modulating collagenCross-link quality and suggest that therapeutic strategies targeting LH2-mediated collagen cross -linking in the TME may be effective in controlling tumor progression and improving disease outcomes.

TL;DR: The catalytically active BRSK2 kinase is established as a negative regulator of NRF2 via the AMPK/mTOR signaling, which may prove useful for therapeutically targetingNRF2 in human diseases.