Ryan Hamnett
Laboratory of Molecular Biology
11 Papers
2 Citations
Ryan Hamnett is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Circadian rhythm & Suprachiasmatic nucleus. The author has an hindex of 5, co-authored 8 publications. Previous affiliations of Ryan Hamnett include Stanford University.
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Papers
Insulin/IGF-1 Drives PERIOD Synthesis to Entrain Circadian Rhythms with Feeding Time
Priya Crosby,Ryan Hamnett,Marrit Putker,Nathaniel P. Hoyle,Martin Reed,Carolyn J. Karam,Elizabeth S. Maywood,Alessandra Stangherlin,Johanna E. Chesham,Edward A. Hayter,Lyn Rosenbrier-Ribeiro,Peter Newham,Hans Clevers,David A. Bechtold,John S. O’Neill +14 more
TL;DR: It is proposed insulin and IGF-1 are primary signals of feeding time to cellular clocks throughout the body and require coincident mechanistic target of rapamycin (mTOR) activation, increased phosphoinositide signaling, and microRNA downregulation.
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The VIP-VPAC2 neuropeptidergic axis is a cellular pacemaking hub of the suprachiasmatic nucleus circadian circuit
Andrew P. Patton,Mathew D. Edwards,Nicola J. Smyllie,Ryan Hamnett,Ryan Hamnett,Johanna E. Chesham,Marco Brancaccio,Marco Brancaccio,Elizabeth S. Maywood,Michael H. Hastings +9 more
TL;DR: This work shows that SCN cells expressing vasoactive intestinal polypeptide (VIP) or its cognate receptor, VPAC2, are neurochemically and electrophysiologically distinct, but together they control de novo rhythmicity, setting ensemble period and phase with circuit-level spatiotemporal complexity.
The Cell-Autonomous Clock of VIP Receptor VPAC2 Cells Regulates Period and Coherence of Circadian Behavior
TL;DR: VPAC2-expressing cells are a distinct, functionally powerful subset of the SCN circuit, contributing to computation of ensemble period and maintenance of circadian robustness, and this findings extend the understanding ofSCN circuit topology.
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Comparison of wholemount dissection methods for neuronal subtype marker expression in the mouse myenteric plexus
TL;DR: In this article , the authors compared three commonly used methods of ENS whole-mount dissection: two flat-sheet preparations that differed in the order of microdissection and fixation as well as a rod-mounted peeling technique.
Regional cytoarchitecture of the adult and developing mouse enteric nervous system
Ryan Hamnett,L. B. Dershowitz,Vandana Sampathkumar,Vandana Sampathkumar,Zhangyuan Wang,V. De Andrade,Narayanan Kasthuri,Narayanan Kasthuri,Shaul Druckmann,Julia A. Kaltschmidt +9 more
TL;DR: In this article, the authors visually and computationally demonstrate that the enteric nervous system (ENS) is organized in circumferential stripes that regionally differ in development and neuronal composition, which provides a blueprint for future understanding of region-specific GI function and identifying ENS structural correlates of GI disorders.