Ryan F. Schell
University of North Carolina at Chapel Hill
4 Papers
14 Citations
Ryan F. Schell is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Pharmacokinetics. The author has an hindex of 2, co-authored 4 publications.
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Papers
Meta-analysis of inter-patient pharmacokinetic variability of liposomal and non-liposomal anticancer agents.
Ryan F. Schell,Brian J. Sidone,Brian J. Sidone,Whitney P. Caron,Mark D. Walsh,Taylor F. White,Beth A. Zamboni,Ramesh K. Ramanathan,William C. Zamboni +8 more
TL;DR: The authors determined that several parameters are in favor of the liposomal formulation; however, the PK variability of the formulation was higher compared with small molecule agents, the reason for which remains to be determined in future studies.
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Evaluation of the efficiency of tumor and tissue delivery of carrier-mediated agents (CMA) and small molecule (SM) agents in mice using a novel pharmacokinetic (PK) metric: relative distribution index over time (RDI-OT).
Andrew J. Madden,S. Rawal,Katie Sandison,Ryan F. Schell,Allison N. Schorzman,Allison M. Deal,Lan Feng,Ping Ma,Russell J. Mumper,Joseph M. DeSimone,William C. Zamboni +10 more
TL;DR: In mice bearing flank tumor xenografts, SMs distribute into tumor more efficiently than CMAs, and a novel PK metric entitled relative distribution over time (RDI-OT), which measures efficiency of delivery is indicated.
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Abstract 3355: Evaluation of the efficiency of tumor and tissue delivery of carrier mediated agents (CMA) and small molecule (SM) agents in mice using a novel pharmacokinetic (PK) metric relative distribution index over time (RDI-OT).
Andrew J. Madden,S. Rawal,Kevin S. Chu,Katie Sandison,Ryan F. Schell,Lan Feng,Ping Ma,Russell J. Mumper,Joseph M. DeSimone,William C. Zamboni +9 more
TL;DR: In mice bearing flank tumor xenografts, SMs distribute into tumor more efficiently than CMAs, and a novel PK metric entitled relative distribution over time (RDI-OT), which measures efficiency of delivery is indicated.
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Abstract 1295: Relationship between pharmacokinetic (PK) sampling schema and reported PK variability of liposomes in patients
Ryan F. Schell,Whitney P. Caron,Mark D. Walsh,Beth A. Zamboni,Ramesh K. Ramanathan,William C. Zamboni +5 more
TL;DR: In this article, the authors evaluated the reported inter-patient variability of PEGylated CKD-602 (S-CKD602) and non-liposomal CKD -602 (NL-CKN-602) using a short (0-24 h) and long ( 0-336 h) sampling schema.
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