Ryan Edgar
University of Alberta
12 Papers
122 Citations
Ryan Edgar is an academic researcher from University of Alberta. The author has contributed to research in topics: Transplantation & Islet. The author has an hindex of 9, co-authored 12 publications.
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Papers
Effect of different induction strategies on effector, regulatory and memory lymphocyte sub-populations in clinical islet transplantation
Christian Toso,Ryan Edgar,Rena Pawlick,Juliet Emamaullee,Shaheed Merani,Parastoo Dinyari,Thomas F. Mueller,A. M. James Shapiro,Colin C. Anderson +8 more
TL;DR: The observed altered balance between effector, regulatory and memory cells suggests that the immune status of patients will be affected according to the induction strategy chosen.
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Sirolimus drug-eluting, hydrogel-impregnated polypropylene mesh reduces intra-abdominal adhesion formation in a mouse model
Allison H. Maciver,Michael McCall,Ryan Edgar,Aducio Thiesen,David L. Bigam,Thomas A. Churchill,A. M. James Shapiro +6 more
TL;DR: Creation of a sirolimus drug-eluting and hydrogel-impregnated polypropylene mesh resulted in marked decrease of adhesion formation in this mouse model, was well tolerated without side effects, and has potential for clinical application.
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Porcine Marginal Mass Islet Autografts Resist Metabolic Failure Over Time and Are Enhanced by Early Treatment with Liraglutide
Juliet Emamaullee,Shaheed Merani,Christian Toso,Tatsuya Kin,Faisal Al-Saif,Wayne Truong,Rena Pawlick,Joy Davis,Ryan Edgar,Jennifer Lock,Susan Bonner-Weir,Lotte Bjerre Knudsen,A. M. James Shapiro +12 more
TL;DR: Surprisingly, no evidence for deterioration of graft function was observed in any of the transplanted animals over more than 18 months of follow-up despite significant weight gain; in fact, an enhanced response to glucose developed over time even in control animals.
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Vascular endothelial growth factor expression in hepatic epithelioid hemangioendothelioma: Implications for treatment and surgical management
Juliet Emamaullee,Ryan Edgar,Christian Toso,Aducio Thiesen,Vincent G. Bain,David L. Bigam,Norman M. Kneteman,A. M. James Shapiro +7 more
TL;DR: Analysis of the expression of the angiogenic factor vascular endothelial growth factor (VEGF) and its receptors in hepatic EHE suggests that anti‐VEGF chemotherapeutic agents will be of use in patients with liver transplantation, particularly as a means of reducing the tumor volume prior to resection.
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The caspase inhibitor IDN-6556 (PF3491390) improves marginal mass engraftment after islet transplantation in mice.
Michael McCall,Christian Toso,Christian Toso,Juliet Emamaullee,Rena Pawlick,Ryan Edgar,Joy Davis,Allison H. Maciver,Tatsuya Kin,Robert H. Arch,A. M. James Shapiro +10 more
TL;DR: The effectiveness of caspase inhibition with IDN-6556 on islet transplantation and in particular islet engraftment and survival is demonstrated and protective effects in vitro for islet viability are found.
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