Ryan E. Morgan
Amgen
8 Papers
72 Citations
Ryan E. Morgan is an academic researcher from Amgen. The author has contributed to research in topics: Bile acid & Bile Salt Export Pump. The author has an hindex of 7, co-authored 8 publications.
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Papers
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Ryan E. Morgan,Michael Trauner,Carlo van Staden,Paul H. Lee,Bharath Ramachandran,Michael Eschenberg,Cynthia A. Afshari,Charles W. Qualls,Ruth Lightfoot-Dunn,Hisham K. Hamadeh +9 more
TL;DR: In this study, membrane vesicles harvested from BSEP-transfected insect cells were used to assess the activity of more than 200 benchmark compounds to thoroughly investigate the relationship between interference with BSEp function and liver injury, and suggest a relatively strong association between the pharmacological interference with bile salt export pump function and human hepatotoxicity.
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A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Ryan E. Morgan,Carlo van Staden,Yuan Chen,Natarajan Kalyanaraman,Jackson Kalanzi,Robert T. Dunn,Cynthia A. Afshari,Hisham K. Hamadeh +7 more
TL;DR: The relationship between clinical evidence of liver injury and effects to multidrug resistance-associated proteins (MRPs) believed to play a role in BA homeostasis is investigated and integration of exposure data, and knowledge of an effect to not only BSEP but also one or more of the MRPs, is a useful tool for informing the potential for liver injury.
231
In vitro assays and biomarkers for drug-induced phospholipidosis
TL;DR: Any screening approach, while assessing the potential to induce phospholipidosis, must be considered in relation to prediction of findings in vivo, and the status of current assays and biomarkers is presented with strategies for screening.
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Membrane vesicle ABC transporter assays for drug safety assessment.
Carlo van Staden,Ryan E. Morgan,Bharath Ramachandran,Yuan Chen,Paul H. Lee,Hisham K. Hamadeh +5 more
TL;DR: This model can be used to influence the drug development process at an early stage and provide rapid feedback regarding the selection of compounds for advancement to in vivo safety evaluations.
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Individual serum bile acid profiling in rats aids in human risk assessment of drug-induced liver injury due to BSEP inhibition.
Steven Cepa,David Potter,Lisa Wong,Leah Schutt,Jacqueline M. Tarrant,Jodie Pang,Xiaolin Zhang,Roxanne Andaya,Laurent Salphati,Yingqing Ran,Le An,Ryan E. Morgan,Jonathan Maher +12 more
TL;DR: Serum bile acid profiling can potentially identify a mechanistic risk of clinical DILI that could be poorly detected by traditional toxicity endpoints, according to traditional toxicity testing.
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