Ryan Chaban
University of Mainz
19 Papers
25 Citations
Ryan Chaban is an academic researcher from University of Mainz. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 2, co-authored 8 publications.
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Papers
Pig heart and lung xenotransplantation: Present status.
TL;DR: The recent pig heart transplant in a patient at the University of Maryland Medical Center has stimulated renewed interest in the xenotransplantation of organs from genetically engineered pigs as discussed by the authors , but their utility for destination therapy remains uncertain.
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In-vitro examination of the positive inotropic effect of caffeine and taurine, the two most frequent active ingredients of energy drinks
Ryan Chaban,Angela Kornberger,N. Branski,K. Buschmann,Nicole Stumpf,Andres Beiras-Fernandez,Christian-Friedrich Vahl +6 more
TL;DR: While caffeine altered the contraction behavior of the specimen significantly in the authors' in-vitro model, taurine did not exhibit a significant effect.
Shooting for the moon: Genome editing for pig heart xenotransplantation.
TL;DR: The first human-to-pig transplant from a gene-edited pig has been reported in this paper , which is considered a major milestone in the development of human-human transplantation.
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Future of Lung Transplantation: Xenotransplantation and Bioengineering Lungs.
Justin C Y Chan,Ryan Chaban,Stephanie H. Chang,Luis F. Angel,Robert A. Montgomery,Richard N. Pierson +5 more
TL;DR: In this article , the current status of lung xenotransplantation, and challenges related to immunology, physiology, anatomy, and infection are discussed, and tissue engineering as a feasible alternative to develop a viable lung replacement solution is discussed.
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Knock‐out of N‐glycolylneuraminic acid attenuates antibody‐mediated rejection in xenogenically perfused porcine lungs
Ryan Chaban,Zahra Alikhassy Habibabady,Wessam Hassanein,Margaret R. Connolly,Lars Burdorf,Emily Redding,Christopher Laird,Jolene Ranek,Gheorghe Braileanu,Selin Sendil,Wenjie Sun,Natalie A. O'Neill,Kasinath Kuravi,Sunghoon Hurh,David Ayares,Agnes M. Azimzadeh,Richard N. Pierson +16 more
TL;DR: Additional Neu5GcKO in GalTKO significantly reduces parameters associated with antibody-mediated inflammation and activation of the coagulation cascade and should be beneficial to reduce innate immune antigenicity of porcine lungs in future human recipients.
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