/pdf/pharmaceutical-nanotechnology-from-the-bench-to-the-market-rccxvdks.pdf

Pharmaceutical nanotechnology: from the bench to the market

Nanoparticles (NPs) have remarkable properties for delivering therapeutic drugs to the body’s targeted cells. NPs have shown to be significantly more efficient as drug delivery carriers than micron-sized particles, which are quickly eliminated by the immune system. Biopolymer-based polymeric nanoparticles (PNPs) are colloidal systems composed of either natural or synthetic polymers and can be synthesized by the direct polymerization of monomers (e.g., emulsion polymerization, surfactant-free emulsion polymerization, mini-emulsion polymerization, micro-emulsion polymerization, and microbial polymerization) or by the dispersion of preformed polymers (e.g., nanoprecipitation, emulsification solvent evaporation, emulsification solvent diffusion, and salting-out). The desired characteristics of NPs and their target applications are determining factors in the choice of method used for their production. This review article aims to shed light on the different methods employed for the production of PNPs and to discuss the effect of experimental parameters on the physicochemical properties of PNPs. Thus, this review highlights specific properties of PNPs that can be tailored to be employed as drug carriers, especially in hospitals for point-of-care diagnostics for targeted therapies.

/pdf/exploring-various-techniques-for-the-chemical-and-biological-2auxrk0g.pdf

Exploring Various Techniques for the Chemical and Biological Synthesis of Polymeric Nanoparticles

Potential utilization of dairy industries by-products and wastes through microbial processes: A critical review

Recent trends and developments on integrated biochemical conversion process for valorization of dairy waste to value added bioproducts: A review.

Valorization of dairy waste and by-products through microbial bioprocesses

Study of Galactooligosaccharides production from dairy waste by FTIR and chemometrics as Process Analytical Technology

Lactic and glycolic acid (PLGA) copolymer nanoparticles of less than 200 nm were produced to trap and transport N acetylcysteine (NAC) to be used in future applications, in the field of drug delivery systems. To do this, we selected the simple emulsion and evaporation method, using ethyl acetate as a solvent, Pluronic F127® as a surfactant, water and used ultrasound to generate the emulsion. The effect of the parameters during the organic to the aqueous phase was assessed as well as the amplitude and sonication. We found nanoparticles of 114 nm that trapped colloidally stable 15% NAC; the ratio of organic to the aqueous phase was 1 to 5, the amplitude 60% and the ultrasound period was 60 s.

/pdf/produccion-de-nanoparticulas-de-plga-por-el-metodo-de-1zrwov20xb.pdf

Producción de nanopartículas de PLGA por el método de emulsión y evaporación para encapsular N-Acetilcisteína (NAC)

http://www.scielo.org.co/pdf/unsc/v19n2/v19n2a09.pdf

PLGA nanoparticles production by emulsion and evaporation to encapsulate N-acetylcysteine (NAC)

Produção de nanopartículas de PLGA pelo método de emulsão e evaporação para encapsular N-Acetilcisteína (NAC)

N-Acetylcysteine (NAC) is a hydrophilic compound with a low bioavailability. It has been used as an effective antioxidant agent. This research seeks to enhance the entrapment of NAC in PLGA nanoparticles for drug delivery systems. The nanoparticles were made using the nanoprecipitation method and changing the following parameters: the solvent/nonsolvent nature, its viscosity, pH, NAC addition to the nonsolvent, the polymer concentration and molecular weight, and NAC concentration in the solvent. The results showed that an increase in the nonsolvent viscosity produces NAC concentration in the solvent, and the nonsolvent rises its entrapment in the nanoparticles. Nanoparticles with 235.5 ± 11.4 nm size with an entrapment efficiency of 0.4 ± 0.04% and a specific load of 3.14 ± 0.33% were obtained. The results suggest that besides efficiently entrapping hydrophobic compounds, the nanoprecipitation method also has a high potential as an alternative entrapment method for hydrophilic compounds as well. However, its use in the pharmaceutical industry, as a proper specific load vehicle, still depends on the improvement of the load capacity.

/pdf/improvement-of-n-acetylcysteine-loaded-in-plga-nanoparticles-1zb8seg0wl.pdf

Improvement of N-Acetylcysteine Loaded in PLGA Nanoparticles by Nanoprecipitation Method

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