To analyze the diagnostic efficacy of ultrasound elastography (UE) and dynamic contrast-enhanced MR in benign and malignant breast masses.From August 2016 to May 2019, the medical records of 98 patients with breast masses in the Zhuji Sixth People's Hospital were retrospectively analyzed, including 45 cases of benign tumor and 53 cases of malignancy diagnosed by pathology. All patients were examined by UE and dynamic contrast-enhanced MR imaging. The pathologic results were used as the gold standard, and the detection results of benign and malignant masses under different examinations were observed and compared with pathology to analyze the specificity and sensitivity.The specificity and sensitivity of diagnosis by UE were 94.44% and 86.89% respectively. The specificity and sensitivity of diagnosis by dynamic contrast-enhanced MR imaging were 96.30% and 91.80%, respectively. The specificity and sensitivity of joint diagnosis were 98.36% and 90.74%, respectively.Joint diagnosis can improve the sensitivity in the diagnosis of benign and malignant breast masses. This improves the diagnostic value for breast tumors. 

Diagnostic efficacy of ultrasound elastography and dynamic contrast-enhanced MR in benign and malignant breast masses.

Photoacoustic tomography (PAT) was utilized to investigate the hemodynamics effects of Chuanxiong in localized regions of mice. A four-day continuous gavage was administered to healthy mice (n=10), followed by data acquisition using PAT. It was observed that Chuanxiong influenced the concentration of total hemoglobin (HbT) in the brains and legs of mice. These results suggest a consistent impact of Chuanxiong on HbT concentration across various regions in mice, highlighting the potential of PAT in advancing our understanding of the action mechanisms of Chinese herbal medications and enhancing their clinical applications. 

Photoacoustic Tomography to Observe Hemodynamic Changes Induced by Chuanxiong in Mice

Detailed insight into the radiation-induced changes in tumor microvasculature is crucial to maximize the efficacy of radiotherapy against breast cancer. Recent advances in imaging have enabled precise targeting of solid lesions. However, intratumoral heterogeneity makes treatment planning and monitoring more challenging. Conventional imaging cannot provide high-resolution observation and longitudinal monitoring of large-scale microvascular in response to radiotherapy directly in deep tissues. Herein, we report on an emerging non-invasive imaging assessment method of morphological and functional tumor microvasculature responses with high spatio-temporal resolution by means of optoacoustic imaging (OAI). In vivo imaging of 4T1 breast tumor response to a conventional fractionated radiotherapy at varying dose (14 × 2 Gy and 3 × 8 Gy) has been performed after 2 weeks following treatment. Remarkably, optoacoustic images can generate richful contrast for the tumor microvascular architecture. Besides, the functional status of tumor microvasculature and tumor oxygenation levels were further estimated using OAI. The results revealed the differential (size-dependent) nature of vascular responses to radiation treatments at varying doses. The vessels exhibited an decrease in their density accompanied by a decline in the number of vascular segments following irradiation, compared to the control group. The measurements further revealed an increase of tumor oxygenation levels for 14 × 2 Gy and 3 × 8 Gy irradiations. Our results suggest that OAI could be used to assess the response to radiotherapy based on changes in the functional and morphological status of tumor microvasculature, which are closely linked to the intratumor microenvironment. OAI assessment of the tumor microenvironment such as oxygenation status has the potential to be applied to precise radiotherapy strategy.

/pdf/noninvasive-optoacoustic-imaging-of-breast-tumor-1d999oy9.pdf

Noninvasive optoacoustic imaging of breast tumor microvasculature in response to radiotherapy

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Noninvasive optoacoustic imaging of breast tumor microvasculature in response to radiotherapy