Runfeng Li
Guangzhou Medical University
33 Papers
119 Citations
Runfeng Li is an academic researcher from Guangzhou Medical University. The author has contributed to research in topics: Virus & Medicine. The author has an hindex of 10, co-authored 19 publications.
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Papers
The tree shrew provides a useful alternative model for the study of influenza H1N1 virus
Zifeng Yang,Zifeng Yang,Jin Zhao,Yu-tong Zhu,Yutao Wang,Rong Liu,Suishan Zhao,Runfeng Li,Chunguang Yang,Ji-qiang Li,Nanshan Zhong +10 more
TL;DR: It is proposed that tree shrews could be a useful alternative mammalian model to study pathogenesis of influenza H1N1 virus.
Inhibition of the infectivity and inflammatory response of influenza virus by Arbidol hydrochloride in vitro and in vivo (mice and ferret).
Yutao Wang,Yuewen Ding,Chunguang Yang,Runfeng Li,Qiuling Du,Yanbing Hao,Li Zhengtu,Haiming Jiang,Jin Zhao,Qiaoyan Chen,Zifeng Yang,Zifeng Yang,Zhanlong He +12 more
TL;DR: The results clarified the activity of ARB in both suppressing virus propagation and modulating the expression of inflammatory cytokines in vitro and in vivo, it can be as an effective drug to treat the influenza virus infection.
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Imidazole-based pinanamine derivatives: Discovery of dual inhibitors of the wild-type and drug-resistant mutant of the influenza A virus.
Jianghong Dong,Shengwei Chen,Runfeng Li,Wei Cui,Haiming Jiang,Yixia Ling,Zifeng Yang,Wenhui Hu +7 more
TL;DR: In this article, a structure-activity relationship study of a series of imidazole-linked pinanamine derivatives was conducted by modifying the imidaze ring of this compound, which was identified as being active on an amantadine-sensitive virus through blocking of the viral M2 ion channel.
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Efficacy of delayed treatment of China-made Peramivir with repeated intravenous injections in a mouse influenza model: from clinical experience to basal experiment
Li Zhengtu,Runfeng Li,Jing Li,Hui Xie,Yanbing Hao,Qiuling Du,Tingting Chen,Yimin Li,Rongchang Chen,Zifeng Yang,Zifeng Yang,Nanshan Zhong,Nanshan Zhong +12 more
TL;DR: Delayed treatment with China-made Peramivir can reduce the severity of influenza disease, accelerate viral clearance and enhance the survival rate, and this drug shows good efficacy and is a promising candidate to control the influenza epidemic in China.
Tropism and innate host responses of influenza A/H5N6 virus: an analysis of ex vivo and in vitro cultures of the human respiratory tract
Kenrie P Y Hui,Louisa L. Y. Chan,Denise I. T. Kuok,Chris Ka Pun Mok,Zifeng Yang,Runfeng Li,Geraldine S. M. Luk,Elaine F. Lee,Jimmy C. C. Lai,Hui-Ling Yen,Hongbo Zhu,Yi Guan,John M. Nicholls,J. S. Malik Peiris,Michael C. W. Chan +14 more
TL;DR: While the human H5N6 virus had affinity for avian-like receptors, the two avian isolates had binding affinity for bothAvian- and human- like receptors and all three H5n6 viruses were less potent inducers of pro-inflammatory cytokines compared with H1N1 virus.
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