9 Papers
140 Citations
Run An is an academic researcher from Chinese Center for Disease Control and Prevention. The author has contributed to research in topics: Scrapie & Oxidative stress. The author has an hindex of 8, co-authored 9 publications. Previous affiliations of Run An include Xi'an Jiaotong University.
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Papers
The N-terminus of PrP is responsible for interacting with tubulin and fCJD related PrP mutants possess stronger inhibitive effect on microtubule assembly in vitro.
Chenfang Dong,Song Shi,Xiao-Fan Wang,Run An,Ping Li,Jian-Ming Chen,Xin Wang,Gui-Rong Wang,Bing Shan,Bao-Yun Zhang,Jun Han,Xiao-Ping Dong +11 more
TL;DR: The molecular interaction between PrP and tubulin was confirmed using pull-down assays, immunoprecipitation and ELISA and the familial Cruetzfeldt Jacob disease related PrP mutants with inserted or deleted octapeptide repeats showed much stronger inhibitive capacities on the microtubule dynamics in vitro than wild-type PrP.
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Different expression patterns of CK2 subunits in the brains of experimental animals and patients with transmissible spongiform encephalopathies.
Jian-Ming Chen,Chen Gao,Qi Shi,Bing Shan,Yan-Jun Lei,Yan-Jun Lei,Chenfang Dong,Run An,Run An,Gui-Rong Wang,Bao-Yun Zhang,Jun Han,Xiao-Ping Dong +12 more
TL;DR: The results suggest that alterations of CK2 subunits in brains are illness-correlative phenomena in TSEs and indicate a potential linkage of CK1 changes with the pathogenesis of prion diseases.
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Molecular interaction between prion protein and GFAP both in native and recombinant forms in vitro
Chenfang Dong,Xiao-Fan Wang,Xin Wang,Xin Wang,Song Shi,Gui-Rong Wang,Bing Shan,Run An,Run An,Xiaoli Li,Bao-Yun Zhang,Jun Han,Xiao-Ping Dong +12 more
TL;DR: The study of the association of PrP with GFAP supplies the molecular evidence for the observation of co-localization ofPrPSc and GFAP in the brains of TSEs and may further provide insight into a potential role of GF AP in the biological function of Prp and the pathogenesis of prion diseases.
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Development of a multiplex PCR method for detecting and typing human papillomaviruses in verrucae vulgaris
Yan-Jun Lei,Chen Gao,Run An,Qi Shi,Jian-Ming Chen,Yu-Kang Yuan,Chen Wang,Jun Han,Xiao-Ping Dong +8 more
TL;DR: A novel multiplex PCR method that allows detecting and typing HPV DNA simultaneously in one reaction based on the length of the PCR products after electrophoresis provides a useful additional tool for the clinical epidemiological study of verrucae vulgaris.
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PrP mutants with different numbers of octarepeat sequences are more susceptible to the oxidative stress.
Run An,Chenfang Dong,Yan-Jun Lei,Yan-Jun Lei,Lu Han,Ping Li,Jian-Ming Chen,Gui-Rong Wang,Qi Shi,Chen Gao,Hui-Ying Jiang,Wei Zhou,Jun Han,Yonglie Chu,Xiao-Ping Dong +14 more
TL;DR: Data provided the evidences that the octarepeats number within PrP is critical for maintaining its activity of antioxidation, which may be one of the possible pathways for the mutated PrPs to involve in the pathogenesis of familial Creutzfeldt-Jacob diseases.
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