Ruiling Mu
National Institutes of Health
2 Papers
Ruiling Mu is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Effector. The author has an hindex of 2, co-authored 2 publications.
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Papers
Two Distinct Binding Modes Define the Interaction of Brox with the C-Terminal Tails of CHMP5 and CHMP4B.
Ruiling Mu,Vincent Dussupt,Jiansheng Jiang,Paola Sette,Victoria Rudd,Watchalee Chuenchor,Nana F. Bello,Fadila Bouamr,Tsan Sam Xiao +8 more
TL;DR: It is demonstrated that hydrophobic residues at the CHMP4B C-terminal amphipathic α helix bind a concave surface of Brox, a mammalian paralog of Alix, and insights are provided into the overlapping but distinct binding profiles of ESCRT-III and the Bro1 domain proteins.
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The Phe105 Loop of Alix Bro1 Domain Plays a Key Role in HIV-1 Release
Paola Sette,Ruiling Mu,Vincent Dussupt,Jiansheng Jiang,Greg A. Snyder,Patrick F. Smith,Tsan Sam Xiao,Fadila Bouamr +7 more
TL;DR: The crystal structures of the Bro1 domains of HD-PTP and Brox are solved and a new functional determinant is identified in the Bro 1 domain of Alix that alleviates HIV-1 release defects that result from interrupted access to ESCRT.