Ruifeng Lu
University of Arizona
5 Papers
53 Citations
Ruifeng Lu is an academic researcher from University of Arizona. The author has contributed to research in topics: Tight junction & Biology. The author has an hindex of 5, co-authored 5 publications.
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Papers
Rab14 regulation of claudin-2 trafficking modulates epithelial permeability and lumen morphogenesis
TL;DR: Epithelial permeability is regulated by targeted insertion and recycling of tight junction proteins and depletion of Rab14 results in increased transepithelial resistance and aberrant morphogenesis in three-dimensional culture.
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PKCι interacts with Rab14 and modulates epithelial barrier function through regulation of claudin-2 levels
TL;DR: PKCι has an essential role in epithelial polarity and its knockdown increases epithelial barrier through control of the trafficking of claudin-2 through interaction with small GTPase Rab14.
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Rab14 specifies the apical membrane through Arf6-mediated regulation of lipid domains and Cdc42.
Ruifeng Lu,Jean M. Wilson +1 more
TL;DR: Rab14 regulates trafficking of vesicles to the apical domain, mitotic spindle orientation, and midbody position, consistent with Rab14’s reported localization to the midbody as well as its effects upon Cdc42, which position Rab14 at the top of a molecular cascade that regulates the establishment of cell polarity.
Scaffolding protein GOPC regulates tight junction structure
TL;DR: In Madin-Darby canine kidney (MDCK) cells, it is found that GOPC localizes to the trans-Golgi network (TGN) but not to the cis- or trans-TGN cisternae and no localization of GOPC was detected to the lateral membranes or tight junctions.
Endosomal regulation of contact inhibition through the AMOT:YAP pathway
Christopher M. Cox,Edward K. Mandell,Lorraine Stewart,Ruifeng Lu,Debra L. Johnson,Sarah D. McCarter,Andre L.P. Tavares,Raymond B. Runyan,Sourav Ghosh,Jean M. Wilson +9 more
TL;DR: It is shown that endotubin regulates YAP localization on endosomes through its interaction with AMOT and thus may play a role in contact inhibition.