Predicting cell-penetrating peptides

The electrochemical behavior of different size gold nanoparticles (AuNPs) was investigated. AuNPs with 2, 5, 10, 15, 20 and 50 nm diameters were immobilized onto a screen printed carbon electrode surface by physical adsorption. The impedimetric response was measured for different diameter AuNPs at a fixed value of their surface area, at the same content of gold (Au) and at the same concentration. In a further experiment, the impedimetric response toward AuNP concentration was measured for each diameter. Impedimetric results were compared with results obtained for the detection of Au by stripping voltammetry. Additionally, variability of active surface area and roughness of different electrodes before and after immobilization of AuNPs were carefully evaluated by means of cyclic voltammetry and laser scanning microscopy. Electrochemical impedance spectroscopy (EIS) is a sensitive technique capable of differentiating the signal generated by AuNPs of different sizes, thus providing useful information for the employment of AuNPs in electrochemical biosensors.

Influence of gold nanoparticle size (2–50 nm) upon its electrochemical behavior: an electrochemical impedance spectroscopic and voltammetric study

The concentrations of heavy metals (Cr, Co, Ni, Cu, Zn, Pb, Cd, As, Hg, and Fe) in sediments of the Yangtze River, China, were investigated to evaluate levels of contamination and their potential sources. The lowest heavy metal concentrations were found in the source regions of the river basin. Relatively high concentrations of metals, except Cr, were found in the Sichuan Basin, and the highest concentrations were in the Xiangjiang and Shun’anhe rivers. All concentrations, except Ni, were higher than global averages. Principal component analysis and hierarchical cluster analysis showed that Zn, Pb, As, Hg, and Cd were derived mainly from the exploitation of various multi-metal minerals, industrial wastewater, and domestic sewage. Cu, Co, and Fe were derived mainly from natural weathering (erosion). Cr and Ni were derived mainly from agricultural activities, municipal and industrial wastewater. Sediment pollution was assessed using the geoaccumulation index (Igeo) and enrichment factor (EF). Among the ten heavy metals assessed, Cd and Pb had the highest Igeo values, followed by Cu, As, Zn, and Hg. The Igeo values of Fe, Cr, Co, and Ni were <0 in all sediments. EF provided similar information to Igeo: no enrichment was found for Cr, Co, and Ni. Cu, Zn, As, and Hg were relatively enriched at some sites while Cd and Pb showed significant enrichment.

Multivariate statistical techniques for evaluating and identifying the environmental significance of heavy metal contamination in sediments of the Yangtze River, China

Synthesis, spectral investigations, antimicrobial activity and DNA-binding studies of novel charge transfer complex of 1,10-phenanthroline as an electron donor with π-acceptor p-Nitrophenol

Electrochemical and Ultraviolet–visible spectroscopic studies on the interaction of deoxyribonucleic acid with vitamin B6

About 20%-30% of genome products have been predicted as membrane proteins, which have significant biological functions The prediction of the amount and position for the transmembrane protein helical segments (TMHs) is the hot spot in bioinformatics In this paper, a new approach, maximum spectrum of continuous wavelet transform (MSCWT), is proposed to predict TMHs The predictions for eight SARS-CoV membrane proteins indicate that MSCWT has the same capacity with software TMpred Moreover, the test on a dataset of 131 structure-known proteins with 548 TMHs shows that the prediction accuracy of MSCWT for TMHs is 916% and that for membrane protein is 893%

/pdf/a-new-approach-to-the-prediction-of-transmembrane-structures-28x0lk0wdu.pdf

A new approach to the prediction of transmembrane structures

In this paper, a named oscillation frequency spectrum (OFS) was developed for the frequency analysis of oscillating signal. Various complexing oscillating chemical reactions, which have been widely applied to analytical determination, were examined. The OFS extracted frequency information of these systems successfully and distinguished their respective frequency characteristics clearly. The details were such that the Belousov-Zhabotinskii (B-Z) system had three frequency peaks and the Cu(II)-catalyzed system had two. Every periodic signal had a special OFS. Even if the frequency values of two different signals were identical, their OFS figures were distinct. The OFS realized the extraction and calculation for the multifrequency characteristic of oscillating chemical system accurately. It followed that OFS could be used to analyze the frequency of periodic signal with accuracy and was suitable for many areas. Copyright © 2006 John Wiley & Sons, Ltd.

A reliable approach of frequency analysis and its application for oscillating chemical systems

Genetic engineering has inserted the crystallin (Cry) gene of Bacillus thuringiensis into the genes of maize to cultivate a variety of transgenic insect-resistant maizes. At present, genetically modified maize with Cry1Ab-ma gene (maize CM8101) was in the stage of safety verification. In this study, a 1-year chronic toxicity test was carried out to evaluate the safety of maize CM8101. Wistar rats were selected for the experiment. Rats were randomly divided into three groups and fed the corresponding diets: genetically modified maize group (CM8101 group), parental maize group (Zheng58 group), and AIN group. Rat serum and urine were collected at the third, sixth, and twelfth months of the experiment, and viscera were collected at the end of the experiment for detection. Metabolomics was used to analyze the metabolites in the serum of rats at the 12th month. While the CM8101 group rats' diets were supplemented with 60% maize CM8101, no obvious poisoning symptoms were found in rats, and no poisoning death occurred. There were no negative effects on body weight, food intake, blood and urine indices, or organ histopathological examination results. Furthermore, metabolomics results revealed that, when compared to group differences, the gender of rats had a more obvious effect on metabolites. The CM8101 group primarily changed linoleic acid metabolism in female rats, while glyceropholipid metabolism was altered in male rats. In rats, consumption of maize CM8101 did not result in significant metabolic dysfunction.

Chronic Toxicity of Genetically Modified Maize with Cry1Ab-ma Gene and Its Effect on Serum Metabolites in Rats.

Simple Summary Todarodes pacificus is an important cephalopod. This study analyzed the migration path and feeding ecology of T. pacificus by the stable isotope values of the proostracum of the gladius. This result showed that T. pacificus in the East China Sea migrated to low latitudes and nearshore areas during their life history, and the trophic level of their food exhibited no large changes during migration. T. pacificus in the Sea of Japan migrated to high latitudes and offshore areas during their life history, and the trophic level of their food decreased during migration. When the proostracum grew to 120 mm from the distal end, T. pacificus in both areas began to migrate. This study provides a scientific basis for further study on the fishery ecology and life history of T. pacificus. Abstract The Japanese flying squid (Todarodes pacificus) is an important cephalopod in the northwest Pacific Ocean. In this study, the proostracum of the gladius of T. pacificus samples collected by Chinese squid fishing vessels in the East China Sea and the Sea of Japan in August and December 2018 were continuously cut, and stable isotope values of the cut fragments were used to analyze the migration path and feeding ecology of T. pacificus. The results showed that when the proostracum grew to 120 mm from the distal end, T. pacificus began to migrate. In the East China Sea, T. pacificus migrated to low latitudes and nearshore areas, and the trophic level of their food showed no large changes during migration. In the Sea of Japan, T. pacificus migrated to high latitudes and offshore areas, and the trophic level of their food showed a decreasing trend during migration. There was no significant difference in migration or feeding ecology between females and males, but the competitive capacity of the females may be stronger than that of the males. The results provided a scientific basis for the scientific management and development of T. pacificus resources.

/pdf/study-on-the-geographic-variation-and-trophic-variation-of-3ahklylr.pdf

Study on the Geographic Variation and Trophic Variation of Todarodes pacificus in Different Areas Based on Stable Isotope Information from the Gladius

Studies on the interaction between antibiotics and DNA.

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