Rui Ma
Zhengzhou University
8 Papers
14 Citations
Rui Ma is an academic researcher from Zhengzhou University. The author has contributed to research in topics: Experimental autoimmune encephalomyelitis & Medicine. The author has an hindex of 2, co-authored 3 publications.
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Papers
Modulation of the HMGB1/TLR4/NF-κB signaling pathway in the CNS by matrine in experimental autoimmune encephalomyelitis.
Yaojuan Chu,Yilei Jing,Xiaoyu Zhao,Mengru Wang,Mingliang Zhang,Rui Ma,Wendi Ma,Ying Lv,Lin Zhu +8 more
TL;DR: In this paper, the authors showed that MAT treatment alleviated disease severity of ongoing EAE, reduced inflammatory infiltration and demyelination, and reduced the production of inflammatory factors including TNF-α, IL-6, and IL-1β in the CNS.
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Ferroptosis as a mechanism of oligodendrocyte loss and demyelination in experimental autoimmune encephalomyelitis
Xinyu Li,Yaojuan Chu,Rui Ma,Mengmeng Dou,Silu Li,Yi-Fan Song,Ying Lv,Lin Zhu +7 more
TL;DR: In this article , the spinal cord of mice with experimental autoimmune encephalomyelitis (EAE), an animal model of MS, was tested to substantiate the relationship between ferroptosis and oligodendrocyte (OL) loss and demyelination.
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Matrine treatment induced an A2 astrocyte phenotype and protected the blood-brain barrier in CNS autoimmunity.
TL;DR: This paper showed that MAT treatment inhibited the generation of neurotoxic A1 astrocytes and promoted neuroprotective A2 astroccytes in the CNS of EAE, most likely by inhibiting production of the A1inducing cytokine cocktail.
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Illumination of Molecular Pathways in Multiple Sclerosis Lesions and the Immune Mechanism of Matrine Treatment in EAE, a Mouse Model of MS.
Mengmeng Dou,Xueliang Zhou,Lifeng Li,Mingliang Zhang,Wang Wenbin,Mengru Wang,Yilei Jing,Rui Ma,Jie Zhao,Lin Zhu +9 more
TL;DR: Zhang et al. as discussed by the authors investigated the pathogenesis and potential therapeutic targets of MS and defined target genes of matrine, a quinolizidine alkaloid component derived from the root of Sophorae flavescens that effectively suppressed experimental autoimmune encephalomyelitis (EAE), an animal model of MS.
Matrine inhibits the Wnt3a/β-catenin/TCF7L2 signaling pathway in experimental autoimmune encephalomyelitis
Rui Ma,Yaojuan Chu,Mengmeng Dou,Yilei Jing,Xiaoyu Zhao,Xinyu Li,Silu Li,Yuan-Ting Zhang,Limei Wang,Lin Zhu +9 more
TL;DR: In this paper , the authors explored MAT's regulatory mechanism on the Wnt/β-catenin/TCF7L2 pathway, a negative modulator for myelination, in MOG35--55 peptide-induced EAE mice.
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