24 Papers
18 Citations
Rui Ma is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 6, co-authored 14 publications.
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Papers
Rufomycin Targets ClpC1 Proteolysis in Mycobacterium tuberculosis and M. abscessus.
Mary P. Choules,Nina M. Wolf,Hyun Lee,Jeffrey R. Anderson,Edyta M. Grzelak,Yuehong Wang,Rui Ma,Wei Gao,James B. McAlpine,Ying Yu Jin,Jinhua Cheng,Hanki Lee,Joo Won Suh,Nguyen Minh Duc,Seungwha Paik,Jin Ho Choe,Eun-Kyeong Jo,Chulhun L. Chang,Jong-Seok Lee,Birgit U. Jaki,Guido F. Pauli,Scott G. Franzblau,Sang-Hyun Cho +22 more
TL;DR: Rufomycin I (RUFI) was found to be a potent and selective lead compound for both M. tuberculosis and Mycobacterium abscessus, providing evidence that although these peptides share ClpC1 as a macromolecular target, their downstream effects are distinct, likely due to differences in binding.
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Antimicrobial Lavandulylated Flavonoids from a Sponge-Derived Streptomyces sp. G248 in East Vietnam Sea.
Duc Danh Cao,Thi Thanh Van Trinh,Huong Doan Thi Mai,Van Nam Vu,Hong Minh Le,Quyen Vu Thi,Mai Anh Nguyen,Thu Trang Duong,Dang Thach Tran,Van Minh Chau,Rui Ma,Gauri Shetye,Sang-Hyun Cho,Brian T. Murphy,Van Cuong Pham +14 more
TL;DR: Three new lavandulylated flavonoids, (2S,2″S)-6-lavandulyl-7,4′-dimethoxy-5,2′-dihydroxylflavanone, along with seven known compounds 4–10 were isolated from culture broth of Streptomyces sp.
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Pyrazole and imidazo[1,2-b]pyrazole Derivatives as New Potential Antituberculosis Agents.
Elda Meta,Chiara Brullo,Michele Tonelli,Scott G. Franzblau,Yuehong Wang,Rui Ma,Wan Baojie,Beatrice Silvia Orena,Maria Rosalia Pasca,Olga Bruno +9 more
TL;DR: Performed tests confirmed that both new pyrazoles and imidazo-pyrazoles could represent a new starting point to obtain more potent compounds and further work is now underway to identify the protein targets of this new class of anti-TB agents.
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Isolation of Tryptanthrin and Reassessment of Evidence for Its Isobaric Isostere Wrightiadione in Plants of the Wrightia Genus.
Rhea C. Garcellano,Rhea C. Garcellano,Rhea C. Garcellano,Syed G. A. Moinuddin,Robert P. Young,Mowei Zhou,Mark E. Bowden,Ryan S. Renslow,Yasemin Yesiltepe,Dennis G. Thomas,Sean M. Colby,Christopher D. Chouinard,Gabe Nagy,Isaac K. Attah,Yehia M. Ibrahim,Rui Ma,Scott G. Franzblau,Norman G. Lewis,Alicia M. Aguinaldo,John R. Cort,John R. Cort +20 more
TL;DR: Characterization by NMR and MS, as well as evaluation of the literature describing these compounds, led to the conclusion that wrightiadione (1) was misidentified in the first report of its isolation from W. tomentosa and again in 2015 when reported in W. pubescens and W. religiosa.
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Mce3R Stress-Resistance Pathway Is Vulnerable to Small-Molecule Targeting That Improves Tuberculosis Drug Activities.
Xinxin Yang,Tianao Yuan,Rui Ma,Kieran I. Chacko,Melissa Smith,Gintaras Deikus,Robert Sebra,Andrew Kasarskis,Harm van Bakel,Scott G. Franzblau,Nicole S. Sampson,Nicole S. Sampson +11 more
TL;DR: 6-azasteroid encodes a cholesterol-regulated stress-resistance pathway that is important for pathogenesis and contributes to drug tolerance, and this pathway is vulnerable to small-molecule targeting in live mycobacteria.
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