6 Papers
33 Citations
Rui Han is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Receptor & Prostaglandin E2. The author has an hindex of 6, co-authored 6 publications. Previous affiliations of Rui Han include Albany Medical College & UCLA Medical Center.
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Papers
Unique attributes of orbital fibroblasts and global alterations in IGF-1 receptor signaling could explain thyroid-associated ophthalmopathy.
Terry J. Smith,Chieh Chih Tsai,Mei Ju Shih,Shanli Tsui,Beiling Chen,Rui Han,Vibha Naik,Chris S. King,Chris Press,Shweta Kamat,Robert A. Goldberg,Richard P. Phipps,Raymond S. Douglas,Andrew G. Gianoukakis +13 more
TL;DR: The laboratory group has focused over the last several years on defining the peculiarities of the human orbital fibroblasts as a strategy for shedding more light on the pathologies occurring in TAO, reasoned that unique properties of these cells might ultimately prove the basis for why the manifestations of Graves' disease occur in an anatomically selective manner.
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Robust induction of PGHS-2 by IL-1 in orbital fibroblasts results from low levels of IL-1 receptor antagonist expression
TL;DR: It is reported that human orbital fibroblasts express high levels of prostaglandin-endoperoxide H synthase (PGHS)-2, the inflammatory cyclooxygenase, when treated with IL-1beta, which results from enhanced PGHS-2 mRNA stability and small increases in gene promoter activity.
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Cytoplasmic Prostaglandin E2 Synthase Is Dominantly Expressed in Cultured KAT-50 Thyrocytes, Cells That Express Constitutive Prostaglandin-endoperoxide H Synthase-2: BASIS FOR LOW PROSTAGLANDIN E2PRODUCTION
Rui Han,Terry J. Smith +1 more
TL;DR: It is reported here that KAT-50 cells express high basal levels of cPGES but mPGES mRNA and protein are undetectable, indicating that naturally occurring cells can express a suboptimal profile of PGHS and PGES isoforms, resulting in diminished levels of PGE2generation.
17
Jak2 Dampens the Induction by IL-1β of Prostaglandin Endoperoxide H Synthase 2 Expression in Human Orbital Fibroblasts: Evidence for Divergent Influence on the Prostaglandin E2 Biosynthetic Pathway
TL;DR: It is reported that the induction of PGHS-2 by IL-1β is dramatically enhanced and prolonged when Jak2 signaling is abrogated, either with the specific inhibitor AG490 or by transiently transfecting fibroblasts with a dominant negative mutant Jak2.
7
Induction by IL-1β of Tissue Inhibitor of Metalloproteinase-1 in Human Orbital Fibroblasts: Modulation of Gene Promoter Activity by IL-4 and IFN-γ
Rui Han,Terry J. Smith +1 more
TL;DR: It is reported that orbital fibroblasts treated with IL-1β express high levels of tissue inhibitor of metalloproteinase-1 (TIMP-1), an important modulator of matrix metallOProteinase activity, which could represent an important therapeutic target for modifying the proteolytic environment in TAO.