12 Papers
10 Citations
Rui Fu is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Embryonic stem cell & Induced pluripotent stem cell. The author has an hindex of 9, co-authored 11 publications.
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Papers
Complete Meiosis from Embryonic Stem Cell-Derived Germ Cells In Vitro
Quan Zhou,Quan Zhou,Mei Wang,Mei Wang,Yan Yuan,Yan Yuan,Xuepeng Wang,Rui Fu,Haifeng Wan,Mingming Xie,Mingming Xie,Mingxi Liu,Xuejiang Guo,Ying Zheng,Guihai Feng,Qinghua Shi,Xiaoyang Zhao,Jiahao Sha,Qi Zhou +18 more
TL;DR: Intracytoplasmic injection of the resulting spermatid-like cells into oocytes produced viable and fertile offspring, showing that this robust stepwise approach can functionally recapitulate male gametogenesis in vitro.
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Editing porcine IGF2 regulatory element improved meat production in Chinese Bama pigs.
Guanghai Xiang,Jilong Ren,Tang Hai,Rui Fu,Dawei Yu,Jing Wang,Jing Wang,Wei Li,Haoyi Wang,Qi Zhou +9 more
TL;DR: Results indicated that editing IGF2 intron 3–3072 site using CRISPR–Cas9 technology improved meat production in Bama pigs, the first demonstration that editing non-coding region can improve economic traits in livestock.
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Generation of GGTA1-/-β2M-/-CIITA-/- Pigs Using CRISPR/Cas9 Technology to Alleviate Xenogeneic Immune Reactions
Rui Fu,Minghui Fang,Kai Xu,Jilong Ren,Jun Zou,Long Su,Xinxin Chen,PeiPei An,Dawei Yu,Meina Ka,Tang Hai,Ziyi Li,Wei Li,Yong-Guang Yang,Qi Zhou,Zheng Hu +15 more
TL;DR: It is demonstrated that elimination of GGTA1, β2M, and CIITA genes in pigs can effectively alleviate xenogeneic immune responses and prolong pig organ survival in xenogenesis and will facilitate future research in xenotransplantation.
40
Domesticated cynomolgus monkey embryonic stem cells allow the generation of neonatal interspecies chimeric pigs
Rui Fu,Dawei Yu,Jilong Ren,Chongyang Li,Jing Wang,Guihai Feng,Xuepeng Wang,Haifeng Wan,Tianda Li,Libin Wang,Ying Zhang,Tang Hai,Wei Li,Qi Zhou +13 more
TL;DR: An optimized culture medium is reported that enhanced the anti-apoptotic ability of cmESCs and improved the development of chimeric embryos, and the capability of D-ESCs to integrate and differentiate into functional cells in a porcine model is demonstrated.
Generation of transgenic rats through induced pluripotent stem cells.
Minggui Jiang,Minggui Jiang,Tianda Li,Chunjing Feng,Rui Fu,Yan Yuan,Yan Yuan,Quan Zhou,Quan Zhou,Xin Li,Xin Li,Haifeng Wan,Liu Wang,Wei Li,Yamei Xiao,Xiaoyang Zhao,Qi Zhou +16 more
TL;DR: An optimized induction medium containing knock-out serum replacement and vitamin C improved the rate and efficiency of riPSCs generation from Dark Agouti rat fibroblasts and Sertoli cells and could generate high quality ri PSCs that could be used to produce transgenic rats.
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