4 Papers
2 Citations
Rui Chen is an academic researcher from Cleveland Clinic Lerner Research Institute. The author has contributed to research in topics: Fibroblast growth factor receptor 1 & Cancer stem cell. The author has an hindex of 3, co-authored 4 publications.
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Papers
ADAMDEC1 Maintains a Growth Factor Signaling Loop in Cancer Stem Cells
Ana Jimenez-Pascual,James S. Hale,James S. Hale,Anja Kordowski,Jamie Pugh,Daniel J. Silver,Daniel J. Silver,Defne Bayik,Defne Bayik,Gustavo Roversi,Tyler J. Alban,Tyler J. Alban,Tyler J. Alban,Shilpa Rao,Shilpa Rao,Rui Chen,Thomas M. McIntyre,Thomas M. McIntyre,Thomas M. McIntyre,Giorgio Colombo,Giulia Taraboletti,Karl O. Holmberg,Karin Forsberg-Nilsson,Justin D. Lathia,Justin D. Lathia,Justin D. Lathia,Florian A. Siebzehnrubl +26 more
TL;DR: A novel signaling loop that induces and maintains GSCs consisting of an atypical metalloproteinase, a disintegrin and metallOProteinase domain-like protein decysin 1 (ADAMDEC1), secreted by G SCs is identified.
Epidermal Growth Factor (EGF) Autocrine Activation of Human Platelets Promotes EGF Receptor-Dependent Oral Squamous Cell Carcinoma Invasion, Migration, and Epithelial Mesenchymal Transition.
TL;DR: HMW-EGF in platelet function is established and a previously unsuspected connection between activated platelets and tumorigenesis is elucidated through rapid, and prolonged, autocrine-stimulated release of HMW- EGF by tumor-associated platelets.
Circulating biologically active oxidized phospholipids show on-going and increased oxidative stress in older male mice.
TL;DR: Oxidatively modified phospholipids are increased in the circulation during common, mild oxidant stresses of aging, or in male compared to female animals, with the highest levels being found in older, male mice.
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ADAMDEC1 maintains a novel growth factor signaling loop in cancer stem cells
James S. Hale,Ana Jimenez-Pascual,Anja Kordowski,Jamie Pugh,Shilpa Rao,Daniel J. Silver,Tyler Alban,Defne Bayik Watson,Rui Chen,Thomas M. McIntyre,Thomas M. McIntyre,Giorgio Colombo,Giulia Taraboletti,Karl O. Holmberg,Karin Forsberg-Nilsson,Justin D. Lathia,Justin D. Lathia,Florian A. Siebzehnrubl +17 more
TL;DR: A novel sheddase, a disintegrin and metalloproteinase domain-like protein decysin 1, that initiates a fibroblast growth factor autocrine loop to promote stemness in CSCs is identified and can be targeted to reduce glioblastoma growth.