Rui-Chao Chai
Capital Medical University
42 Papers
22 Citations
Rui-Chao Chai is an academic researcher from Capital Medical University. The author has contributed to research in topics: Glioma & Astrocyte. The author has an hindex of 17, co-authored 41 publications. Previous affiliations of Rui-Chao Chai include Peking University & National Health and Family Planning Commission.
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Papers
Chinese Glioma Genome Atlas (CGGA): A Comprehensive Resource with Functional Genomic Data from Chinese Glioma Patients.
Zheng Zhao,Kenan Zhang,Qiang-Wei Wang,Guanzhang Li,Fan Zeng,Ying Zhang,Fan Wu,Rui-Chao Chai,Zheng Wang,Chuanbao Zhang,Wei Zhang,Zhaoshi Bao,Tao Jiang +12 more
TL;DR: Wang et al. as mentioned in this paper developed the Chinese Glioma Genome Atlas (CGGA), a userfriendly data portal for the storage and interactive exploration of cross-omics data, including nearly 2000 primary and recurrent glioma samples from Chinese cohort.
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Chinese Glioma Genome Atlas (CGGA): A Comprehensive Resource with Functional Genomic Data for Chinese Glioma Patients
Zheng Zhao,Kenan Zhang,Qiangwei Wang,Guanzhang Li,Fan Zeng,Ying Zhang,Fan Wu,Rui-Chao Chai,Zheng Wang,Chuanbao Zhang,Wei Zhang,Zhaoshi Bao,Tao Jiang +12 more
TL;DR: The Chinese Glioma Genome Atlas (CGGA) is developed, a user-friendly data portal for storage and interactive exploration of multi-dimensional functional genomic data that includes nearly 2,000 primary and recurrent glioma samples from Chinese cohorts and develops an analysis tool to allow users to browse mutational, mRNA/microRNA expression, and DNA methylation profiles and perform survival and correlation analyses of specificglioma subtypes.
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m6A RNA methylation regulators contribute to malignant progression and have clinical prognostic impact in gliomas.
Rui-Chao Chai,Fan Wu,Qixue Wang,Shu Zhang,Kenan Zhang,Yu-Qing Liu,Zheng Zhao,Tao Jiang,Yong-Zhi Wang,Chunsheng Kang,Chunsheng Kang +10 more
- 27 Feb 2019
TL;DR: It is demonstrated that most of the thirteen main m6A RNA methylation regulators are differentially expressed among gliomas stratified by different clinicopathological features in 904gliomas, and derived a risk signature that is not only an independent prognostic marker but can also predict the clinicopathic features of glioma malignancy.
YTHDF2 facilitates UBXN1 mRNA decay by recognizing METTL3-mediated m6A modification to activate NF-κB and promote the malignant progression of glioma.
Rui-Chao Chai,Yu-Zhou Chang,Xin Chang,Bo Pang,Song Yuan An,Kenan Zhang,Yuanhao Chang,Tao Jiang,Yongzhi Wang +8 more
TL;DR: In this paper, the role and mechanism of the RNA N6,2′-O-dimethyladenosine (m6A) reader, YTH N6-methyladenosines RNA binding protein 2 (YTHDF2), in regulating the malignant progression of gliomas was investigated.
METTL3 enhances the stability of MALAT1 with the assistance of HuR via m6A modification and activates NF-κB to promote the malignant progression of IDH-wildtype glioma.
Yu-Zhou Chang,Rui-Chao Chai,Bo Pang,Xin Chang,Song Yuan An,Kenan Zhang,Tao Jiang,Yongzhi Wang +7 more
TL;DR: Zhang et al. as discussed by the authors investigated the role and mechanism of the m6A writer METTL3 in regulating the malignant progression of IDH-wildtype gliomas.
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