Rudolph L. Leibel
Columbia University
333 Papers
3.6K Citations
Rudolph L. Leibel is an academic researcher from Columbia University. The author has contributed to research in topics: Leptin & Adipose tissue. The author has an hindex of 89, co-authored 321 publications. Previous affiliations of Rudolph L. Leibel include Howard Hughes Medical Institute & Massachusetts Institute of Technology.
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Papers
Whole-exome sequencing identifies novel LEPR mutations in individuals with severe early onset obesity.
Richard Gill,Richard Gill,Yee Him Cheung,Yufeng Shen,Patricia Lanzano,Nazrat M. Mirza,Nazrat M. Mirza,Svetlana Ten,Noel K. Maclaren,Roja Motaghedi,Joan C. Han,Jack A. Yanovski,Rudolph L. Leibel,Wendy K. Chung +13 more
TL;DR: This work Discoves the relevant genes using positional cloning to account for most of the apparent genetic risk variance in obesity and describes how these genes are switched on and off through the generations.
Constitutive and impaired signaling of leptin receptors containing the Gln → Pro extracellular domain fatty mutation
David White,Yanping Wang,Streamson C. Chua,Jay P. Morgenstern,Rudolph L. Leibel,Heinz Baumann,Louis A. Tartaglia +6 more
TL;DR: In this article, a single amino acid substitution at position 269 (Gln → Pro) in the OB-R extracellular domain that results in the obese phenotype of the fatty rat was analyzed.
Ciliary gene RPGRIP1L is required for hypothalamic arcuate neuron development
Liheng Wang,Alain J. De Solis,Yossef Goffer,Kathryn E. Birkenbach,Staci E. Engle,Ross M. Tanis,Jacob M. Levenson,Xueting Li,Richard Rausch,Manika Purohit,Jen-Yi Lee,Jerica Tan,Maria Caterina De Rosa,Claudia A. Doege,Holly L. Aaron,Gabriela J. Martins,Jens C. Brüning,Dieter Egli,Rui M. Costa,Nicolas F. Berbari,Rudolph L. Leibel,George Stratigopoulos +21 more
TL;DR: It is suggested that apparently functional intronic polymorphisms affect hypothalamic RPGRIP1L expression and impact development of POMC neurons and their derivatives, leading to hyperphagia and increased adiposity.
A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children
Priya Duggal,Xiaoti Guo,Rashidul Haque,Kristine M. Peterson,Stacy M. Ricklefs,Dinesh Mondal,Faisal Alam,Faisal Alam,Zannatun Noor,Hans P. Verkerke,Chelsea Marie,Charles A. LeDuc,Streamson C. Chua,Martin G. Myers,Rudolph L. Leibel,Eric R. Houpt,Carol A. Gilchrist,Alan Sher,Stephen F. Porcella,William A. Petri +19 more
TL;DR: It is suggested that leptin signaling is important in mucosal defense against amebiasis and that polymorphisms in the leptin receptor explain differences in susceptibility of children in the Bangladesh cohort to amebisal.
Roles of the placenta in fetal brain development
TL;DR: The traditional view of the placenta as a passive site of transport of maternal nutrients, growth factors, and hormones needs to be expanded to include a role in supporting CNS development through adaptive responses to the maternal environment.