Rudolph L. Leibel
Columbia University
333 Papers
3.6K Citations
Rudolph L. Leibel is an academic researcher from Columbia University. The author has contributed to research in topics: Leptin & Adipose tissue. The author has an hindex of 89, co-authored 321 publications. Previous affiliations of Rudolph L. Leibel include Howard Hughes Medical Institute & Massachusetts Institute of Technology.
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Papers
Linkages and associations between the leptin receptor (LEPR) gene and human body composition in the Québec Family Study.
Yvon C. Chagnon,Wendy K. Chung,Louis Pérusse,Monique Chagnon,Rudolph L. Leibel,Claude Bouchard +5 more
TL;DR: Results indicate that the LEPR gene is involved in the regulation of the body composition in human particularly of FFM in the QFS.
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Molecular mapping of the mouse db mutation.
TL;DR: P phenotyping of the progeny of these crosses revealed a wide range in plasma concentrations of glucose and insulin among the obese progeny, with some animals developing overt diabetes and other remaining euglycemic.
120
In vitro lipid synthesis in human adipose tissue from three abdominal sites
TL;DR: Investigation of cellular mechanisms that might contribute to enlargement of intra-abdominal adipocytes, lipolysis, triacylglycerol (TG), and diacyl Glyceride (DG) synthesis from [14C]glucose was measured in abdominal subcutaneous, omental, and mesenteric adipose tissue from severely obese women and men.
119
Leptin: a molecule integrating somatic energy stores, energy expenditure and fertility.
TL;DR: A protein secreted by adipocytes, leptin, is identified as a plausible candidate for a humoral signal with the requisite endocrinology and neurobiology.
119
Heterozygosity forLepob orLeprdb affects body composition and leptin homeostasis in adult mice
Wendy K. Chung,Kristen Belfi,Melvin Chua,Jennifer Wiley,Ronald M. Mackintosh,Margery Nicolson,Carol N. Boozer,Rudolph L. Leibel +7 more
TL;DR: The data, and data from a small number of mice heterozygous at both Lepob and Leprdb (compound heterozygotes), suggest that leptin protein produced per mass of body fat is reduced in Lepob /+ mice and that bodyfat is increased in LepOB /- mice until plasma leptin concentrations reach that of a normal +/+ mouse.
117