Ruby Jiang
University of British Columbia
12 Papers
121 Citations
Ruby Jiang is an academic researcher from University of British Columbia. The author has contributed to research in topics: DNA methylation & Methylation. The author has an hindex of 10, co-authored 12 publications. Previous affiliations of Ruby Jiang include Family Research Institute.
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Papers
Androgenetic/biparental mosaicism causes placental mesenchymal dysplasia
Kathleen Kaiser-Rogers,Deborah E. McFadden,Chad A. Livasy,Jerome Dansereau,Ruby Jiang,Judith Knops,Louis Lefebvre,Kathleen W. Rao,Wendy P. Robinson +8 more
TL;DR: Androgenetic mosaicism for the first time provides an aetiology for PMD, and may be a novel mechanism for Beckwith-Wiedemann syndrome and unexplained intrauterine growth restriction.
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Genome-wide mapping of imprinted differentially methylated regions by DNA methylation profiling of human placentas from triploidies.
Ryan K. C. Yuen,Ryan K. C. Yuen,Ruby Jiang,Ruby Jiang,Maria S. Peñaherrera,Maria S. Peñaherrera,Deborah E. McFadden,Wendy P. Robinson,Wendy P. Robinson +8 more
TL;DR: Comparison of DNA methylation for known imprinted genes between placentas of different gestations and other somatic tissues provides a detailed analysis of specific CpG sites associated with tissue-specific imprinting and gestational age-specific methylation.
Skewed X-Chromosome Inactivation Is Associated with Trisomy in Women Ascertained on the Basis of Recurrent Spontaneous Abortion or Chromosomally Abnormal Pregnancies
C. L. Beever,Mary D. Stephenson,Maria S. Peñaherrera,Ruby Jiang,Dagmar K. Kalousek,Michael R. Hayden,L. Leigh Field,Carolyn J. Brown,Wendy P. Robinson +8 more
TL;DR: It is hypothesized that the association between skewed XCI and trisomic pregnancies is produced by a common mechanism that underlies both and that involves a reduction of the size of the follicular pool.
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Patterns of placental development evaluated by X chromosome inactivation profiling provide a basis to evaluate the origin of epigenetic variation
Maria S. Peñaherrera,Ruby Jiang,Ruby Jiang,Luana Avila,Luana Avila,Ryan K. C. Yuen,Ryan K. C. Yuen,Carolyn J. Brown,Wendy P. Robinson,Wendy P. Robinson +9 more
TL;DR: The patterns of XCI skewing are consistent with a model whereby each biopsied site of chorionic villi represents one or a few individual villus trees, each of which is clonally derived from only one orA few precursor cells.
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Methylation of ZNF261 as an assay for determining X chromosome inactivation patterns.
C. L. Beever,Betty P.Y. Lai,Sarah E. L. Baldry,Maria S. Peñaherrera,Ruby Jiang,Wendy P. Robinson,Carolyn J. Brown +6 more
TL;DR: The highly polymorphic ZNF261 gene is adapted for methylation-based analysis of X inactivation, which is a candidate for X-linked mental retardation and shows highest expression in brain, although expression is found in all tissues examined.
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