Ru Chen
University of Washington
49 Papers
408 Citations
Ru Chen is an academic researcher from University of Washington. The author has contributed to research in topics: Pancreatic cancer & Cancer. The author has an hindex of 31, co-authored 49 publications.
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Papers
Mass spectrometry based glycoproteomics - from a proteomics perspective
TL;DR: An overview of the recent advances in mass spectrometry based glycoproteomic methods and technology, in the context of biomarker discovery and clinical application is provided.
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Quantitative Proteomics Analysis Reveals That Proteins Differentially Expressed in Chronic Pancreatitis Are Also Frequently Involved in Pancreatic Cancer
Ru Chen,Teresa A. Brentnall,Sheng Pan,Kelly Cooke,Kara White Moyes,Zhaoli Lane,David A. Crispin,David R. Goodlett,Ruedi Aebersold,Mary P. Bronner +9 more
TL;DR: This study used ICAT technology and tandem mass spectrometry-based proteomics to systematically study protein expression in chronic pancreatitis and validated that cathepsin D, integrin β1, and plasminogen were overexpressed in both pancreatic cancer and chronic pancitis.
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Proteomic Profiling of Pancreatic Cancer for Biomarker Discovery
TL;DR: Recent progress and challenges for applying quantitative proteomics technologies for biomarker discovery in pancreatic cancer are discussed.
157
Protein alterations associated with pancreatic cancer and chronic pancreatitis found in human plasma using global quantitative proteomics profiling.
Sheng Pan,Ru Chen,David A. Crispin,Damon May,Tyler Stevens,Martin W. McIntosh,Mary P. Bronner,Argyrios Ziogas,Hoda Anton-Culver,Teresa A. Brentnall +9 more
TL;DR: The protein candidates identified in this study provide a biomarker candidate pool for future investigations and may benefit the development of plasma proteomics technology in general.
Unexpected gain of function for the scaffolding protein plectin due to mislocalization in pancreatic cancer
Soo J. Shin,Jeffrey A. Smith,Günther A. Rezniczek,Günther A. Rezniczek,Sheng Pan,Ru Chen,Teresa A. Brentnall,Gerhard Wiche,Kimberly A. Kelly +8 more
TL;DR: It is shown that plectin, which was previously identified as a biomarker for pancreatic ductal adenocarcinoma, has important function for tumor pathogenesis and the mechanism, exosomes, through which this occurs is identified.
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