Rozaleen Dash
Indian Institute of Technology Delhi
11 Papers
8 Citations
Rozaleen Dash is an academic researcher from Indian Institute of Technology Delhi. The author has contributed to research in topics: Chemistry & Peptide. The author has an hindex of 3, co-authored 8 publications. Previous affiliations of Rozaleen Dash include All India Institute of Medical Sciences & Indian Institutes of Technology.
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Papers
Assessment of structural and functional similarity of biosimilar products: Rituximab as a case study
TL;DR: An analytical similarity exercise that was performed with five biosimilars of rituximab (Ristova®, Roche), a chimeric mouse/ human monoclonal antibody biotherapeutic, that are available on the Indian market shows that, while the biosimilar exhibited similarity with respect to protein structure and function, there were significant differences withrespect to size heterogeneity, charge heterogeneity and glycosylation pattern.
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Impact of mAb Aggregation on Its Biological Activity: Rituximab as a Case Study.
TL;DR: Investigating how mAb aggregates generated by a variety of mechanical, thermal and chemical stresses impact the biological activity of a biotherapeutic affirm that understanding of the mechanism of aggregation is critical for achieving consistent product quality and the resulting efficacy.
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A novel piperazine derivative that targets hepatitis B surface antigen effectively inhibits tenofovir resistant hepatitis B virus
S Kiruthika,Ruchika Bhat,Rozaleen Dash,Anurag S. Rathore,Perumal Vivekanandan,Bhyravabhotla Jayaram +5 more
TL;DR: In this paper, the authors used computational virtual screening, docking, and molecular dynamics simulations to identify potential small molecule inhibitors against hepatitis B surface antigen (HBsAg) in serum.
Template-based design of peptides to inhibit SARS-CoV-2 RNA-dependent RNA polymerase complexation
TL;DR: Development and application of a structural bioinformatics protocol to design peptides that can inhibit RdRp complex formation by targeting the interface of its core subunit nonstructural protein (nsp) 12 with accesory factor nsp7 are reported.
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An efficient computational protocol for template-based design of peptides that inhibit interactions involving SARS-CoV-2 proteins.
Akshay Chenna,Wajihul Hasan Khan,Rozaleen Dash,Saurabh Saraswat,Archana Chugh,Anurag S. Rathore,Gaurav Goel +6 more
TL;DR: In this paper , the interaction hotspots of the nsp7-nsp12 subunit of the RNA-dependent RNA polymerase (RdRp) complex, determined from a long molecular dynamics trajectory, are used as a template.
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