Roy J. Blackburn
University of South Florida
6 Papers
Roy J. Blackburn is an academic researcher from University of South Florida. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 1, co-authored 2 publications.
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Papers
Adeno-associated viral vectors for functional intravenous gene transfer throughout the non-human primate brain.
Miguel R. Chuapoco,Nicholas C. Flytzanis,Nick Goeden,K. M. Roxas,Ken Y. Chan,Jon Scherrer,Janet Winchester,Roy J. Blackburn,Lillian Campos,Kwun Nok Mimi Man,Junqing Sun,Xinhong Chen,Vikram Singh,Cynthia Mary Arokiaraj,Timothy F. Shay,Julia Vendemiatti,Min Jee Jang,John K. Mich,Yemeserach Bishaw,Bryan B. Gore,Victoria Omstead,Naz Taskin,Natalie Weed,Boaz P. Levi,Jonathan T. Ting,Cory T. Miller,Benjamin E. Deverman,James Pickel,Lin Tian,Andrew S. Fox,Viviana Gradinaru +30 more
TL;DR: CAP-Mac is shown to have potential for non-invasive systemic gene transfer in the brains of non-human primates and applications of a single, intravenous dose of CAP-Mac to deliver functional GCaMP for ex vivo calcium imaging across multiple brain areas, or a cocktail of fluorescent reporters for Brainbow-like labelling throughout the macaque brain, circumventing the need for germline manipulations.
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Early Life Stress and High FKBP5 Interact to Increase Anxiety-Like Symptoms through Altered AKT Signaling in the Dorsal Hippocampus.
Marangelie Criado-Marrero,Niat T. Gebru,Lauren A. Gould,Taylor M. Smith,Sojeong Kim,Roy J. Blackburn,Chad A. Dickey,Laura J. Blair +7 more
TL;DR: Biochemically, Protein kinase B (AKT) phosphorylation was reduced in the dorsal hippocampus in rTgFKBP5 mice, which demonstrates that significant molecular changes occur as a result of ELS when FKBP5 levels are altered.
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Benzothiazole Substitution Analogs of Rhodacyanine Hsp70 Inhibitors Modulate Tau Accumulation.
Shannon E. Hill,David Beaulieu-Abdelahad,A Lara Lemus,Jack M. Webster,Santiago Rodriguez Ospina,April L. Darling,Mackenzie D. Martin,Shreya Patel,Roy J. Blackburn,Laurent Calcul,Chad A. Dickey,James W. Leahy,Laura J. Blair +12 more
TL;DR: In this paper , eight analogs of the rhodacyanine inhibitor, JG-98, were synthesized and evaluated, and three compounds, representing divergent clogP values, were evaluated for in vivo blood-brain barrier penetration and tau reduction in an ex vivo brain slice model.
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Hsp70-Family Proteins and Neurodegenerative Diseases
Zheying Sun,Roy J. Blackburn,Laura J. Blair,John Koren +3 more
- 01 Jan 2018
TL;DR: This chapter will discuss the studies and tools which elucidated the role of Hsp70 family members in neurodegenerative disorders and will offer perspective into therapeutic interventions which may prove beneficial for treating these diseases.
Intravenous gene transfer throughout the brain of infant Old World primates using AAV
Miguel R. Chuapoco,Nicholas C. Flytzanis,Nick Goeden,J. Christopher Octeau,K. M. Roxas,Ken Y. Chan,Jon Scherrer,Janet Winchester,Roy J. Blackburn,Lillian Campos,Cynthia Mary Arokiaraj,Timothy F. Miles,Min Jee Jang,Julia Vendemiatti,Benjamin E. Deverman,James Pickel,Andrew S. Fox,Viviana Gradinaru +17 more
TL;DR: CAP-Mac is an engineered AAV variant that enables systemic, brain-wide gene delivery in infants of two Old World primate species and shows promise for researchers and clinicians alike to unlock novel, noninvasive access to the brain for efficient gene transfer.