Ross Laybutt
Garvan Institute of Medical Research
13 Papers
143 Citations
Ross Laybutt is an academic researcher from Garvan Institute of Medical Research. The author has contributed to research in topics: Insulin & Insulin resistance. The author has an hindex of 10, co-authored 13 publications. Previous affiliations of Ross Laybutt include Harvard University & University of New South Wales.
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Papers
Translational Control Is Required for the Unfolded Protein Response and In Vivo Glucose Homeostasis
Donalyn Scheuner,Benbo Song,Edward L. McEwen,Chuan Liu,Ross Laybutt,Patrick J. Gillespie,Thom Saunders,Susan Bonner-Weir,Randal J. Kaufman +8 more
TL;DR: It is demonstrated that regulation of translation through eIF2alpha phosphorylation is essential for the ER stress response and in vivo glucose homeostasis.
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MicroRNAs contribute to compensatory β cell expansion during pregnancy and obesity.
Cécile Jacovetti,Amar Abderrahmani,Géraldine Parnaud,Jean-Christophe Jonas,Marie-Line Peyot,Marion Cornu,Ross Laybutt,Emmanuelle Meugnier,Sophie Rome,Bernard Thorens,Marc Prentki,Domenico Bosco,Romano Regazzi +12 more
TL;DR: Blockade of miR-338-3p in β cells using specific anti-miR molecules mimicked gene expression changes occurring during β cell mass expansion and resulted in increased proliferation and improved survival both in vitro and in vivo.
Glucose Transporter (GLUT-4) Is Targeted to Secretory Granules in Rat Atrial Cardiomyocytes
Jan W. Slot,Gabriella Garruti,Sally Martin,Viola Oorschot,George Posthuma,Edward W. Kraegen,Ross Laybutt,Gaétan Thibault,David E. James +8 more
TL;DR: The data suggest that a large proportion of GLUT-4 must recycle via the TGR in insulin-sensitive cells, and it will be important to determine if this is the pathway by which the insulin-regulatable tubulo-vesicular compartment is formed.
Low serum PYY is linked to insulin resistance in first-degree relatives of subjects with type 2 diabetes
Dana Boey,Leonie K. Heilbronn,Amanda Sainsbury,Ross Laybutt,Adamandia D. Kriketos,Herbert Herzog,Lesley V. Campbell,Lesley V. Campbell +7 more
TL;DR: Data demonstrate that lack of PYY enhances insulin secretion from the Islets of Langerhans and that low fasting PYY levels are associated with insulin resistance in humans, and suggest that low circulating levels of PYC could contribute to hyperinsulinemia and insulin resistance, and possibly contribute to subsequent development of obesity and type 2 diabetes.
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Casitas b-Lineage Lymphoma–Deficient Mice Are Protected Against High-Fat Diet–Induced Obesity and Insulin Resistance
Juan Carlos Molero,Samuel G. Waring,Adrian Cooper,Nigel Turner,Ross Laybutt,Gregory J. Cooney,David E. James +6 more
TL;DR: Examination of the effect of a high-fat diet on energy homeostasis and glucose metabolism in Casitas b-lineage lymphoma mice shows consistent with a role for c-Cbl in regulating nutrient partitioning in skeletal muscle and emphasizes the potential of the protein as a therapeutic target in the treatment of obesity and type 2 diabetes.
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