Rose Hendrix

TL;DR: High-density oligoarray technology is useful for screening gene expression in transplanted tissues undergoing acute rejection and is likely to yield novel insights into the mechanisms and diagnosis of rejection.

TL;DR: The results suggest that there may be a donor-derived radiosensitive element that enhances allograft survival in this model and imply that complex mechanisms may be important for the induction and maintenance of transplantation tolerance in the CTLA4-Ig plus bone marrow murine cardiac allografted model.

TL;DR: It is reported that skin and cardiac allografts without evidence of inflammation are vigorously rejected by transferred T cells or when recipients are reconstituted with T cells at a physiologic rate by nude bone graft transplantation, suggesting that in the absence of central deletional tolerance, peripheral tolerance mechanisms are not sufficient to inhibit alloimmune responses even in the presence of inflammation or danger.

TL;DR: It is observed that Fas transcripts are constitutively expressed in syngeneic and allogeneic murine cardiac transplants, while Fas ligand (FasL) is up-regulated only in rejecting allografts, suggesting that the Fas pathway may be principally involved in the regulation of clonal expansion and subsequent contraction of T cell populations during immune responses.