Rosandra N. Kaplan
National Institutes of Health
70 Papers
45 Citations
Rosandra N. Kaplan is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Metastasis & Tumor microenvironment. The author has an hindex of 24, co-authored 49 publications. Previous affiliations of Rosandra N. Kaplan include Cornell University & Memorial Sloan Kettering Cancer Center.
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Papers
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
Héctor Peinado,Maša Alečković,Simon Lavotshkin,Irina Matei,Bruno Costa-Silva,Gema Moreno-Bueno,Marta Hergueta-Redondo,Caitlin Williams,Guillermo García-Santos,Cyrus M. Ghajar,Ayuko Nitadori-Hoshino,Caitlin Hoffman,Karen Badal,Benjamin A. Garcia,Margaret K. Callahan,Jianda Yuan,Vilma R. Martins,Johan Skog,Rosandra N. Kaplan,Mary S. Brady,Jedd D. Wolchok,Jedd D. Wolchok,Paul B. Chapman,Paul B. Chapman,Yibin Kang,Yibin Kang,Jacqueline Bromberg,Jacqueline Bromberg,David Lyden +28 more
TL;DR: The data show that exosome production, transfer and education of bone marrow cells supports tumor growth and metastasis, has prognostic value and offers promise for new therapeutic directions in the metastatic process.
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
Rosandra N. Kaplan,Rebecca D. Riba,Stergios Zacharoulis,Anna H. Bramley,Loic Vincent,Carla Costa,Daniel D. MacDonald,David K. Jin,Koji Shido,Scott A. Kerns,Zhenping Zhu,Daniel J. Hicklin,Yan Wu,Jeffrey L. Port,Nasser K. Altorki,Elisa Port,Davide Ruggero,Sergey V. Shmelkov,Kristian K. Jensen,Shahin Rafii,David Lyden +20 more
TL;DR: A requirement for VEGFR1+ haematopoietic progenitor cells that express vascular endothelial growth factor receptor 1 (VEGFR1) home to tumour-specific pre-metastatic sites and form cellular clusters before the arrival of tumour cells is demonstrated.
4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors
Adrienne H. Long,Waleed Haso,Jack F. Shern,Kelsey Wanhainen,Meera Murgai,Maria Ingaramo,Jillian P. Smith,Alec J. Walker,M. Eric Kohler,Vikas R Venkateshwara,Rosandra N. Kaplan,George H. Patterson,Terry J. Fry,Rimas J. Orentas,Crystal L. Mackall +14 more
TL;DR: It is shown that tonic CAR CD3-ζ phosphorylation, triggered by antigen-independent clustering of CAR single-chain variable fragments, can induce early exhaustion of CAR T cells that limits antitumor efficacy, and that CD28 costimulation augments, whereas 4-1BB costimulations reduces, exhaustion induced by persistent CAR signaling.
Pre-metastatic niches: organ-specific homes for metastases
Héctor Peinado,Haiying Zhang,Irina Matei,Bruno Costa-Silva,Ayuko Hoshino,Gonçalo Rodrigues,Gonçalo Rodrigues,Bethan Psaila,Rosandra N. Kaplan,Jacqueline Bromberg,Yibin Kang,Mina J. Bissell,Thomas R. Cox,Amato J. Giaccia,Janine T. Erler,Sachie Hiratsuka,Cyrus M. Ghajar,David Lyden,David Lyden +18 more
TL;DR: This Review summarizes the main processes and new mechanisms involved in the formation of the pre-metastatic niche and describes the main mechanisms used to modify organs of future metastasis.
Disruption of CXCR2-mediated MDSC tumor trafficking enhances anti-PD1 efficacy
Steven L. Highfill,Yongzhi Cui,Amber J. Giles,Jillian P. Smith,Hua Zhang,Elizabeth Morse,Rosandra N. Kaplan,Crystal L. Mackall +7 more
TL;DR: CXCR2+CD11b+Ly6Ghi MDSCs mediate local immunosuppression, which limits the efficacy of checkpoint blockade in murine RMS, and is identified as a novel target for modulating tumor immune escape.
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