Ronald Frank

TL;DR: Diversity and chemical space coverage of the collection indicate that it is highly diverse and well-placed in the chemical space spanned by bioactive compounds, and secondary assay-validated hits presented in this study show the practical relevance of the library design strategy.

TL;DR: A novel dual reporter gene assay of the complete HCV life cycle was developed and a number of molecules that specifically inhibit HCV cell entry, or primarily virus assembly and release, and also identified molecules that increase viral propagation were identified.

TL;DR: The final EU‐OPENSCREEN library, assembled by merging five independent selections of 40K compounds from various expert groups, represents an excellent example of a Europe‐wide collaborative effort toward the common objective of building best‐in‐class European open screening platforms.

TL;DR: In the quest for new targets for antitumor therapy, the proteasome and its inhibitors have been the focus of academic and industrial research and data already support the high potential of argyrin A as a potential drug candidate, but detailed structure–activity relationship studies, and a molecular understanding of its mode-of-action are a prerequisite for the further optimization of its medicinal potential.