Ronald Chan
University of Sydney
4 Papers
2 Citations
Ronald Chan is an academic researcher from University of Sydney. The author has contributed to research in topics: Translocator protein & Cannabinoid. The author has an hindex of 3, co-authored 4 publications. Previous affiliations of Ronald Chan include Australian Nuclear Science and Technology Organisation.
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Papers
Positron emission tomography and functional characterization of a complete PBR/TSPO knockout
Richard B. Banati,Ryan J. Middleton,Ronald Chan,Claire R. Hatty,Winnie Wai-Ying Kam,Candice Quin,Manuel B. Graeber,Arvind Parmar,David Zahra,Paul D. Callaghan,Sandra Fok,Nicholas R. Howell,Marie Gregoire,Alexander M Szabo,Tien Pham,Emma Davis,Guo Jun Liu,Guo Jun Liu +17 more
TL;DR: It is shown that global C57BL/6-Tspotm1GuWu(GuwiyangWurra)-knockout mice are viable with normal growth, lifespan, cholesterol transport, blood pregnenolone concentration, protoporphyrin IX metabolism, fertility and behaviour, and while the activation of microglia after neuronal injury appears to be unimpaired, microglial output is significantly less ATP, suggesting reduced metabolic activity.
The 18 kDa translocator protein, microglia and neuroinflammation.
Guo Jun Liu,Ryan J. Middleton,Claire R. Hatty,Winnie Wai-Ying Kam,Winnie Wai-Ying Kam,Ronald Chan,Tien Pham,Meredith Harrison-Brown,Meredith Harrison-Brown,Eoin Dodson,Kelly Veale,Richard B. Banati +11 more
TL;DR: Against prediction, full Tspo knockout mice are viable and across their lifespan do not show the phenotype expected if cholesterol transport and steroid synthesis were significantly impaired, so the “translocation” function of TSPO remains to be better substantiated.
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Functional gains in energy and cell metabolism after TSPO gene insertion.
Guo Jun Liu,Ryan J. Middleton,Winnie Wai-Ying Kam,David Y. Chin,Claire R. Hatty,Ronald Chan,Richard B. Banati +6 more
TL;DR: It is demonstrated that TSPO gene insertion causes increased transcription of genes involved in the mitochondrial electron transport chain and increased mitochondrial ATP production as well as cell excitability, reflected in a decrease in patch clamp recorded rectified K channel currents.
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Testicular Translocator Protein Expression is Differentially Altered by Synthetic Cannabinoid HU210 in Adult and Adolescent Rats
TL;DR: The results suggest that cannabinoids may alter testosterone production by altering the expression of testicular TSPO and that the alteration of T SPO occurs in an age-dependent manner.