Ron Krofft
University of Washington
7 Papers
232 Citations
Ron Krofft is an academic researcher from University of Washington. The author has contributed to research in topics: Podocyte & Cell cycle. The author has an hindex of 7, co-authored 7 publications.
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Papers
Podocytes that detach in experimental membranous nephropathy are viable.
Arndt T. Petermann,Ron Krofft,Mary Blonski,Keiju Hiromura,Michael G. Vaughn,Raimund Pichler,Sian Griffin,Takehiko Wada,Jeffrey W. Pippin,Raghu V. Durvasula,Stuart J. Shankland +10 more
TL;DR: Although podocyte number increased transiently during the first 5 days ex vivo, apoptosis increased significantly thereafter, reducing overall cell number, suggesting that detached podocytes are viable.
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Cyclin-Dependent Kinase 5 Is a Regulator of Podocyte Differentiation, Proliferation, and Morphology
Siān V. Griffin,Keiju Hiromura,Jeffrey W. Pippin,Arndt T. Petermann,Mary Blonski,Ron Krofft,Satoru Takahashi,Ashok B. Kulkarni,Stuart J. Shankland +8 more
TL;DR: Data suggest a role for CDK5 as a regulator of podocyte differentiation, proliferation, and morphology in differentiated cultured podocytes, either pharmacologically or with siRNA, induced shape changes, with cellular elongation and loss of process formation compared to the characteristic arborized phenotype.
Albumin-induced apoptosis of glomerular parietal epithelial cells is modulated by extracellular signal-regulated kinase 1/2
Alice M. Chang,Takamoto Ohse,Ron Krofft,Jimmy S. Wu,Allison A. Eddy,Jeffrey W. Pippin,Stuart J. Shankland +6 more
TL;DR: A normal role of PECs is to take up filtered albumin, however, this is increased in proteinuric glomerular diseases, leading to apoptosis through changes in ERK1/2.
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SSeCKS sequesters cyclin D1 in glomerular parietal epithelial cells and influences proliferative injury in the glomerulus.
Bettina Burnworth,Jeff Pippin,Prasanthi Karna,Shin Akakura,Ron Krofft,Guoqiang Zhang,Kelly L. Hudkins,Charles E. Alpers,Kelly D. Smith,Stuart J. Shankland,Irwin H. Gelman,Peter J. Nelson +11 more
TL;DR: It is shown that the Src-suppressed protein kinase C substrate (SSeCKS), a multivalent scaffolding A kinase anchoring protein, sequesters cyclin D1 in the cytoplasm of quiescent PECs and influences proliferative injury in the glomerulus.
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Role of smooth muscle protein SM22α in glomerular epithelial cell injury.
Caroline B. Marshall,Ron Krofft,Mary Blonski,Jolanta Kowalewska,Christine M. Logar,Jeffrey W. Pippin,Francis Kim,Robert Feil,Charles E. Alpers,Stuart J. Shankland +9 more
TL;DR: It is concluded that the de novo expression of SM22α in glomerular epithelial cells affects the course of crescentic glomerulonephritis, and there was decreased activation of Erk1/2 in diseased SM22 α +/+ mice.
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