Ron Kriz
Pfizer
14 Papers
193 Citations
Ron Kriz is an academic researcher from Pfizer. The author has contributed to research in topics: Endoplasmic reticulum & HEK 293 cells. The author has an hindex of 10, co-authored 14 publications.
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Papers
Crystal structure of a human IκB kinase β asymmetric dimer.
Shenping Liu,Yohann R. Misquitta,Andrea Olland,Mark Johnson,Kerry Kelleher,Ron Kriz,Laura Lin,Mark Stahl,Lidia Mosyak +8 more
TL;DR: High resolution structure of hIKKβ provides structural basis for its activation and potential use of inhibitor design and may represent trans-phosphorylation steps that accompany IKKβ activation.
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The structure of the Lingo-1 ectodomain, a module implicated in central nervous system repair inhibition.
Lidia Mosyak,Andrew Wood,Brian Dwyer,Madhavan R. Buddha,Mark H. Johnson,Ann Aulabaugh,Xiaotian Zhong,Eleonora Presman,Susan Benard,Kerry Kelleher,James E. Wilhelm,Mark Stahl,Ron Kriz,Ying Gao,Zixuan Cao,Huai-Ping Ling,Menelas N. Pangalos,Frank S. Walsh,William S. Somers +18 more
TL;DR: The structure of the ligand-binding ectodomain of human Lingo-1 has a bimodular, kinked structure composed of leucine-rich repeat (LRR) and immunoglobulin (Ig)-like modules and biophysical analysis of its solution properties reveals that in the crystals and in solution Linge-1 persistently associates with itself to form a stable tetramer, suggesting a model for protein assembly on the membrane.
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Triad of polar residues implicated in pH specificity of acidic mammalian chitinase
Andrea Olland,James Strand,Eleonora Presman,Robert M. Czerwinski,Diane Joseph-McCarthy,Rustem Krykbaev,Gerhard Schlingmann,Rajiv Chopra,Laura Lin,Margaret Fleming,Ron Kriz,Mark Stahl,William S. Somers,Lori Fitz,Lidia Mosyak +14 more
TL;DR: The novel structure of the AMCase catalytic domain, both in the apo form and in complex with the inhibitor methylallosamidin, determined to high resolution by X‐ray crystallography provides a structural basis for understanding some of the unique characteristics of this enzyme, including the low pH optimum and the preference for the β‐anomer of the substrate.
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Regulation of Secreted Frizzled-related Protein-1 by Heparin
Xiaotian Zhong,Thamara Desilva,Laura Lin,Peter V.N. Bodine,Ramesh A. Bhat,Eleonora Presman,Jennifer Pocas,Mark Stahl,Ron Kriz +8 more
TL;DR: It is reported that heparin can specifically enhance recombinant sFRP-1 accumulation in a cell type-specific manner, and requires O-sulfation in heparIn, and involves fibroblast growth factor-2 as well as fibro Blast growth factor receptor-1.
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H6PDH interacts directly with 11β-HSD1: Implications for determining the directionality of glucocorticoid catalysis
Yan-Ling Zhang,Xiaotian Zhong,Zheni Gjoka,Yuanhong Li,Wayne Stochaj,Mark Stahl,Ron Kriz,James Tobin,David V. Erbe,Vipin Suri +9 more
TL;DR: Ex expression and purification of full-length and truncated N-terminal domain (NTD) of H6PDH are reported, indicating that the NTD of H 6PDH is sufficient for the regulation of the 11beta-HSD1 activity.
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