Romina Burla
Sapienza University of Rome
21 Papers
1 Citations
Romina Burla is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Lamin & Biology. The author has an hindex of 9, co-authored 16 publications. Previous affiliations of Romina Burla include Institut Gustave Roussy.
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Papers
AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance
Romina Burla,Mariateresa Carcuro,Grazia D. Raffa,Alessandra Galati,Domenico Raimondo,Angela Maria Rizzo,Mattia La Torre,Emanuela Micheli,Laura Ciapponi,Giovanni Cenci,Enrico Cundari,Antonio Musio,Annamaria Biroccio,Stefano Cacchione,Maurizio Gatti,Isabella Saggio +15 more
TL;DR: It is suggested that AKTIP/Ft1 works in concert with TRF1 to facilitate telomeric DNA replication, a novel mammalian shelterin-bound factor identified on the basis of its homology with the Drosophila telomere protein Pendolino.
The telomeric protein AKTIP interacts with A- and B-type lamins and is involved in regulation of cellular senescence.
Romina Burla,Mariateresa Carcuro,Mattia La Torre,Federica Fratini,Marco Crescenzi,Maria Rosaria D'Apice,Paola Spitalieri,Grazia D. Raffa,Letizia Astrologo,Giovanna Lattanzi,Enrico Cundari,Domenico Raimondo,Annamaria Biroccio,Maurizio Gatti,Isabella Saggio +14 more
TL;DR: The results indicate that AKTIP is a new player in lamin-related processes, including those that govern nuclear architecture, telomere homeostasis and cellular senescence, as well as shelterin-interacting protein required for replication of telomeric DNA.
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Transcriptional Response of Human Neurospheres to Helper-Dependent CAV-2 Vectors Involves the Modulation of DNA Damage Response, Microtubule and Centromere Gene Groups.
Stefania Piersanti,Romina Burla,Valerio Licursi,Catarina Brito,Mattia La Torre,Paula M. Alves,Daniel Simão,Carla Mottini,Sara Salinas,Rodolfo Negri,Enrico Tagliafico,Eric J. Kremer,Isabella Saggio +12 more
TL;DR: The transcriptomic modulation induced by HD-CAV-2 in human differentiated neurospheres derived from midbrain progenitors is analyzed and it is suggested here that the modulation of DNA damage genes is related to viral DNA, while the alteration of centromeric and microtubule probes is possibly enchained by the interaction of the HD-CAV-2 fibre with CAR.
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The Analysis of Pendolino (peo) Mutants Reveals Differences in the Fusigenic Potential among Drosophila Telomeres.
Giovanni Cenci,Laura Ciapponi,Marta Marzullo,Grazia D. Raffa,Patrizia Morciano,Domenico Raimondo,Romina Burla,Isabella Saggio,Maurizio Gatti +8 more
TL;DR: The results suggest that general defects in DNA replication are unable to induce telomeric fusions (TFs) in Drosophila cells and hypothesize that DNA replication in Peo-depleted cells results in specific fusigenic lesions concentrated in heterochromatin-associated telomeres.
Mice with reduced expression of the telomere‐associated protein Ft1 develop p53‐sensitive progeroid traits
Mattia La Torre,Chiara Merigliano,Romina Burla,Carla Mottini,Giorgia Zanetti,Simona Del Giudice,Mariateresa Carcuro,Ilaria Virdia,Elisabetta Bucciarelli,Isabella Manni,Gianluca Rampioni Vinciguerra,Giulia Piaggio,Mara Riminucci,Ana Cumano,Armando Bartolazzi,Fiammetta Vernì,Silvia Soddu,Maurizio Gatti,Isabella Saggio +18 more
TL;DR: The analysis of mice carrying mutations in both Ft1 and p53 showed that reduction in p53 rescues the progeroid traits of Ft1 mutants, suggesting that they are at least in part caused by a p53‐dependent DNA damage response.
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