Roman Effenberg
Institute of Chemical Technology in Prague
5 Papers
Roman Effenberg is an academic researcher from Institute of Chemical Technology in Prague. The author has contributed to research in topics: Liposome & Chemistry. The author has an hindex of 5, co-authored 5 publications.
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Papers
Hyaluronic Acid Surface Modified Liposomes Prepared via Orthogonal Aminoxy Coupling: Synthesis of Nontoxic Aminoxylipids Based on Symmetrically α-Branched Fatty Acids, Preparation of Liposomes by Microfluidic Mixing, and Targeting to Cancer Cells Expressing CD44.
Eliška Bartheldyová,Roman Effenberg,Josef Mašek,Lubomir Prochazka,Pavlína Turánek Knotigová,Pavel Kulich,František Hubatka,Kamila Velínská,Jaroslava Zelníčková,Darina Zouharová,Martina Fojtíková,D. Hrebik,Pavel Plevka,Robert Mikulik,Andrew D. Miller,Stuart Macaulay,Daniel Zyka,Ladislav Drož,Milan Raska,Miroslav Ledvina,Jaroslav Turánek +20 more
TL;DR: These hyaluronic acid-liposomes represent a potentially new drug delivery platform for CD44-targeted anticancer drugs as well as for immunotherapeutics and vaccines.
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The Position of His-Tag in Recombinant OspC and Application of Various Adjuvants Affects the Intensity and Quality of Specific Antibody Response after Immunization of Experimental Mice
Michal Krupka,Josef Mašek,Lucia Barkocziova,Pavlína Turánek Knotigová,Pavel Kulich,Jana Plocková,Róbert Lukáč,Eliška Bartheldyová,Stepan Koudelka,Radka Chaloupková,Marek Šebela,Daniel Zyka,Ladislav Droz,Roman Effenberg,Miroslav Ledvina,Andrew D. Miller,Jaroslav Turánek,Milan Raska +17 more
TL;DR: It is reported that levels of OspC-specific antibodies vary substantially depending upon whether rOspC possesses an N' or C' terminal His-tag, and that Th1-type antibodies predominate post-immunization with rOSpC proteoliposomes formulated with MPLA or MT06 adjuvants.
N-Oxy lipid-based click chemistry for orthogonal coupling of mannan onto nanoliposomes prepared by microfluidic mixing: Synthesis of lipids, characterisation of mannan-coated nanoliposomes and in vitro stimulation of dendritic cells
Eliška Bartheldyová,Pavlína Turánek Knotigová,Kateřina Zachová,Josef Mašek,Pavel Kulich,Roman Effenberg,Daniel Zyka,František Hubatka,Jan Kotouček,Hana Čelechovská,Renata Héžová,Andrea Tomečková,Eliška Mašková,Martina Fojtíková,Stuart Macaulay,Peter Bystrický,Lucia Paulovičová,Ema Paulovičová,Ladislav Drož,Miroslav Ledvina,Milan Raska,Jaroslav Turánek +21 more
TL;DR: The platform based on mannans bound orthogonally onto the surface of nanoliposomes represents a self-adjuvanted carrier for construction of liposome-based recombinant vaccines for both systemic and mucosal routes of administration.
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Nonpyrogenic Molecular Adjuvants Based on norAbu-Muramyldipeptide and norAbu-Glucosaminyl Muramyldipeptide: Synthesis, Molecular Mechanisms of Action, and Biological Activities in Vitro and in Vivo
Roman Effenberg,Pavlína Turánek Knotigová,Daniel Zyka,Hana Čelechovská,Josef Mašek,Eliška Bartheldyová,František Hubatka,Štěpán Koudelka,Róbert Lukáč,Anna Kovalová,David Šaman,Michal Křupka,Lucia Barkocziova,Petr Kosztyu,Marek Šebela,Ladislav Drož,Michal Hučko,Mária Kanásová,Andrew D. Miller,Milan Raska,Miroslav Ledvina,Jaroslav Turánek +21 more
TL;DR: Fatty acyl analogues of muramyldipeptide (MDP) are designed and synthesized comprising the normuramyl-l-α-aminobutanoyl (norAbu) structural moiety, and all new analogues show depressed pyrogenicity in both free (micellar) state and in liposomal formulations when tested in rabbits in vivo.
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BODIPY-based fluorescent liposomes with sesquiterpene lactone trilobolide.
Ludmila Škorpilová,Silvie Rimpelová,Michal Jurášek,Miloš Buděšínský,Jana Lokajová,Roman Effenberg,Petr Slepička,Tomáš Ruml,Eva Kmoníčková,Pavel Drašar,Zdeněk Wimmer +10 more
TL;DR: A new liposomal trilobolide derivative not only retains the biological properties of pure trilOBolide, but also enhances the bioavailability, and thus has potential for the use in theranostic applications.
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