Rolf Klein
Swiss Institute of Bioinformatics
5 Papers
17 Citations
Rolf Klein is an academic researcher from Swiss Institute of Bioinformatics. The author has contributed to research in topics: Population & Error detection and correction. The author has an hindex of 3, co-authored 5 publications.
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Papers
Genotypic tropism testing by massively parallel sequencing: qualitative and quantitative analysis
TL;DR: The combination of MPS and coreceptor usage prediction results in a fast and accurate alternative to phenotypic assays and may allow implementing meaningful cutoffs for predicting response to CCR5-antagonists in the presence of X4-minorities.
Inferring Viral Tropism from Genotype with Massively Parallel Sequencing: Qualitative and Quantitative Analysis
Martin Däumer,Rolf Kaiser,Rolf Klein,Thomas Lengauer,Bernhard Thiele,Alexander Thielen +5 more
- 01 Jan 2008
TL;DR: Viral tropism was predicted with the internal batch-version of geno2pheno[coreceptor] with the prediction-score used as a measure of coreceptor-affinity and quantitative analysis of the R5/X4-distribution was conducted.
Short communication: selection of thymidine analogue resistance mutational patterns in children infected from a common HIV type 1 subtype G source.
Martin Däumer,Sabine Awerkiew,Saleta Sierra Aragón,Vladimir Kartashev,Tatjana Poplavskaja,Rolf Klein,Nadine Sichtig,Bernhard Thiele,Thomas Lengauer,Kirsten Roomp,Herbert Pfister,Rolf Kaiser +11 more
TL;DR: It is speculated that in the context of these subtype G viruses, the development of the T215Y mutation may be strongly disfavored whereas the presence of HLA B*13 may counteract this effect and permit its development.
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15-OR: A Multi-Site Study Employing High Resolution HLA Genotyping by Next Generation 454 GS FLX Sequencing
Cherie Holcomb,Bryan Hoglund,Matthew W. Anderson,Lisbeth A. Blake,Irena Böhme,Michael Egholm,Deborah Ferriola,Christian Gabriel,Damian Goodridge,Rolf Klein,Martha Ladner,Curt Lind,Dimitri S. Monos,Marcelo J. Pando,Johannes Pröll,David Sayer,Gudrun G. Schmitz-Agheguian,Birgitte B. Simen,Bernhard Thiele,Elizabeth Trachtenberg,Dolly B. Tyan,Ralf Wassmuth,Shana White,Henry A. Erlich +23 more
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Error correction of next-generation sequencing data and reliable estimation of HIV quasispecies
TL;DR: It is concluded that pyrosequencing can be used to investigate genetically diverse samples with high accuracy if technical errors are properly treated and probabilistic haplotype inference outperforms the counting-based calling method in both precision and recall.