Rolf Gebhardt
Leipzig University
155 Papers
1.2K Citations
Rolf Gebhardt is an academic researcher from Leipzig University. The author has contributed to research in topics: Glutamine synthetase & Wnt signaling pathway. The author has an hindex of 44, co-authored 153 publications.
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Papers
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.
Patricio Godoy,Nicola J. Hewitt,Ute Albrecht,Melvin E. Andersen,Nariman Ansari,Sudin Bhattacharya,Johannes G. Bode,Jennifer Bolleyn,Christoph Borner,J Böttger,Albert Braeuning,Robert A. Budinsky,Britta Burkhardt,Neil R. Cameron,Giovanni Camussi,Chong Su Cho,Yun Jaie Choi,J. Craig Rowlands,Uta Dahmen,Georg Damm,Olaf Dirsch,María Teresa Donato,Jian Dong,Steven Dooley,Dirk Drasdo,Dirk Drasdo,Dirk Drasdo,Rowena Eakins,Karine Sá Ferreira,Valentina Fonsato,Joanna Fraczek,Rolf Gebhardt,Andrew Gibson,Matthias Glanemann,Christopher E. Goldring,María José Gómez-Lechón,Geny M. M. Groothuis,Lena Gustavsson,Christelle Guyot,David Hallifax,Seddik Hammad,Adam S. Hayward,Dieter Häussinger,Claus Hellerbrand,Philip Hewitt,Stefan Hoehme,Hermann-Georg Holzhütter,J. Brian Houston,Jens Hrach,Kiyomi Ito,Hartmut Jaeschke,Verena Keitel,Jens M. Kelm,B. Kevin Park,Claus Kordes,Gerd A. Kullak-Ublick,Edward L. LeCluyse,Peng Lu,Jennifer Luebke-Wheeler,Anna Lutz,Daniel J. Maltman,Madlen Matz-Soja,Patrick D. McMullen,Irmgard Merfort,Simon Messner,Christoph Meyer,Jessica Mwinyi,Dean J. Naisbitt,Andreas K. Nussler,Peter Olinga,Francesco Pampaloni,Jingbo Pi,Linda J. Pluta,Stefan Przyborski,Anup Ramachandran,Vera Rogiers,Cliff Rowe,Celine Schelcher,Kathrin Schmich,Michael Schwarz,Bijay Singh,Ernst H. K. Stelzer,Bruno Stieger,Regina Stöber,Yuichi Sugiyama,Ciro Tetta,Wolfgang E. Thasler,Tamara Vanhaecke,Mathieu Vinken,Thomas S. Weiss,Agata Widera,Courtney G. Woods,Jinghai James Xu,Kathy Yarborough,Jan G. Hengstler +94 more
TL;DR: This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro and how closely hepatoma, stem cell and iPS cell–derived hepatocyte-like-cells resemble real hepatocytes.
Hepatocyte-Specific Smad7 Expression Attenuates TGF-β–Mediated Fibrogenesis and Protects Against Liver Damage
Steven Dooley,J. Hamzavi,L. Ciuclan,Patricio Godoy,Iryna Ilkavets,Sabrina Ehnert,Elke Ueberham,Rolf Gebhardt,Stephan Kanzler,Andreas Geier,Katja Breitkopf,Honglei Weng,Peter R. Mertens +12 more
TL;DR: The data indicate that hepatocytes undergo TGF-beta-dependent EMT-like phenotypic changes and actively participate in fibrogenesis and ablation of T GF-beta signaling specifically in this cell type is sufficient to blunt the fibrogenic response.
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Tubular Overexpression of Transforming Growth Factor-β1 Induces Autophagy and Fibrosis but Not Mesenchymal Transition of Renal Epithelial Cells
Robert Koesters,Brigitte Kaissling,Michel LeHir,Nicolas Picard,Franziska Theilig,Rolf Gebhardt,Adam B. Glick,Brunhilde Hähnel,Hiltraud Hosser,Hermann Josef Gröne,Wilhelm Kriz +10 more
TL;DR: In conclusion, overexpression of TGF-beta1 in renal tubules in vivo induces interstitial proliferation, tubular autophagy, and fibrosis, but not epithelial-to-mesenchymal transition.
281
Liver zonation: Novel aspects of its regulation and its impact on homeostasis
Rolf Gebhardt,Madlen Matz-Soja +1 more
TL;DR: This review summarizes the fascinating technical achievements for investigating liverZonation and the elucidation of an emerging network of master regulators of zonation that keep the plethora of interrelated and sometimes opposing functions of the liver in balance with nutritional supply and specific requirements of the entire body.
276
New hepatocyte in vitro systems for drug metabolism: metabolic capacity and recommendations for application in basic research and drug development, standard operation procedures.
Rolf Gebhardt,Jan G. Hengstler,Dieter Müller,R. Glöckner,Peter Buenning,Britta Laube,Eva Schmelzer,Martina Ullrich,Dietmar Utesch,Nicola J. Hewitt,M. Ringel,Beate Reder Hilz,Augustinus Bader,Angelika Langsch,Thomas Koose,Hans-Jörg Burger,Jochen Maas,Franz Oesch +17 more
TL;DR: Five in vitro systems with hepatocytes in suspension, perifusion culture systems, liver slices, co-culture systems of hepatocytes with intestinal bacteria, and 96-well plate bioreactors are discussed, which offer the possibility of high throughput and automatization.
275