Rolf Bänteli

TL;DR: The efficient synthesis (10 linear steps) of the potent sLe(x) mimetic 2 is described, which shows a 30-fold improved affinity in a static, cell-free E-selectin-ligand binding assay and is predictive for the in vivo efficacy of test compounds.

TL;DR: Modifications of the already known potent E-selectin antagonist 3 containing a cyclohexyllactic acid residue and a glucal-derived building block are reported on, which indicate topological-structure changes of 6 in the orientation of the neighboring fucose and galactose due to intramolecular steric interactions.

TL;DR: In this paper, the synthesis of the C1N12 tripeptide of the novel immunosuppressant sanglifehrin A was described, and the Evans oxazolidinone methodology was used to install the C8 stereocentre of the meta-tyrosine subunit.

TL;DR: Seven sLe(x) mimics where the -CH2OH group of the galactose moiety is replaced by -CHCH2NH3+, -CH 2NHAc, - CH2NHBz, -CH1OSO3Na, -COONa and -CONH2 have been prepared and tested for their binding affinity to E-selectin.