Roland Ryll
Kitasato University
6 Papers
115 Citations
Roland Ryll is an academic researcher from Kitasato University. The author has contributed to research in topics: Cord factor & Trehalose dimycolate. The author has an hindex of 6, co-authored 6 publications.
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Papers
Mycobacterial cord factor, but not sulfolipid, causes depletion of NKT cells and upregulation of CD1d1 on murine macrophages.
Roland Ryll,Kenji Watanabe,Kenji Watanabe,Nagatoshi Fujiwara,Hiroaki Takimoto,Ryoichi Hasunuma,Yoshio Kumazawa,Masaji Okada,Ikuya Yano +8 more
TL;DR: TDM can initiate a cascade of events starting with strong release of IFN-gamma and NK cell expansion, resulting in the appearance of macrophages activated for antigen presentation, providing the basis for optimized immunization schedules with TDM as the adjuvant component of a Th1 vaccine.
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Suppression of infection-induced endotoxin shock in mice by a citrus flavanone naringin.
Kiichiro Kawaguchi,Sei-ichi Kikuchi,Ryoichi Hasunuma,Hiroko Maruyama,Roland Ryll,Yoshio Kumazawa +5 more
TL;DR: The protective effect of the Citrus flavanone naringin was demonstrated in an endotoxin shock model based on Salmonella infection and suppressed high levels of soluble CD14 and high mobility group-1 molecule caused by infection.
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Differential clearance and induction of host responses by various administered or released lipopolysaccharides.
Ryoichi Hasunuma,Hiroyuki Morita,Shigenori Tanaka,Roland Ryll,Marina A. Freudenberg,Chris Galanos,Yoshio Kumazawa +6 more
TL;DR: Results indicate that continuously higher levels of plasma LPS followed by stronger host responses occur during infection and suggest that these differences between LPS-administered and infected mice should be taken into consideration when analyzing host responses induced by LPS.
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Time- and Dose-Dependent Effect of Fosfomycin on Suppression of Infection-Induced Endotoxin Shock in Mice
Kiichiro Kawaguchi,Ryoichi Hasunuma,Sei-ichi Kikuchi,Roland Ryll,Keiko Morikawa,Yoshio Kumazawa +5 more
TL;DR: Therapeutic effects of fosfomycin and imipenem were investigated in a novel model for endotoxin shock that was caused by intraperitoneal infection with 10(8) colony forming units of attenuated Salmonella typhimurium, suggesting that the antimicrobial activity of FOF seems to closely correlate to suppression of infection-induced lethal shock.
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Does high mobility group 1 protein function as a late mediator for LPS- or TNF-induced shock in galactosamine-sensitized mice?
Ryoichi Hasunuma,Hiroko Maruyama,Hiroaki Takimoto,Roland Ryll,Shigenori Tanaka,Yoshio Kumazawa +5 more
TL;DR: Data suggest that HMG-1 does not decisively contribute to lethality in the GalN sensitization model as well as the time-dependent phenomenon correlated with elevated serum aspartate aminotransferase levels and the appearance of apoptotic cells in livers.
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