Rojina Ranjit
Oklahoma Medical Research Foundation
27 Papers
21 Citations
Rojina Ranjit is an academic researcher from Oklahoma Medical Research Foundation. The author has contributed to research in topics: Medicine & Sarcopenia. The author has an hindex of 8, co-authored 16 publications.
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Papers
Loss of mitochondrial protease ClpP protects mice from diet‐induced obesity and insulin resistance
Shylesh Bhaskaran,Gavin Pharaoh,Gavin Pharaoh,Rojina Ranjit,Ashley Murphy,Satoshi Matsuzaki,Binoj Nair,Brittany Forbes,Suzana Gispert,Georg Auburger,Kenneth M. Humphries,Michael Kinter,Timothy M. Griffin,Sathyaseelan S. Deepa +13 more
TL;DR: An unexpected finding is made that deficiency of ClpP in mice is metabolically beneficial, and it is suggested thatClpP might be dispensable for mammalian UPRmt initiation.
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Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass
Bumsoo Ahn,Gavin Pharaoh,Gavin Pharaoh,Pavithra Premkumar,Kendra Huseman,Rojina Ranjit,Michael Kinter,Michael Kinter,Luke I. Szweda,Tamas Kiss,Gabor A. Fulop,Stefano Tarantini,Anna Csiszar,Zoltan Ungvari,Holly Van Remmen,Holly Van Remmen,Holly Van Remmen +16 more
TL;DR: Graphical abstract fx1 as discussed by the authors is an extension of the fx2-graphical abstract of the Fx1 graph, which is used in this paper, and is used here.
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Oxidative stress‐induced dysregulation of excitation–contraction coupling contributes to muscle weakness
Rizwan Qaisar,Shylesh Bhaskaran,Pavithra Premkumar,Rojina Ranjit,Kavithalakshmi Satara Natarajan,Bumsoo Ahn,Kaitlyn Riddle,Dennis R. Claflin,Arlan Richardson,Arlan Richardson,Arlan Richardson,Susan V. Brooks,Holly Van Remmen,Holly Van Remmen +13 more
TL;DR: The goal of this study is to define the effect of oxidative stress and ageing on muscle weakness and the Excitation Contraction (EC) coupling machinery in age‐matched adult (8–10 months) wild‐type (WT) and Sod1−/− mice in comparison with old (25–28 months) WT mice.
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Restoration of SERCA ATPase prevents oxidative stress-related muscle atrophy and weakness.
Rizwan Qaisar,Shylesh Bhaskaran,Rojina Ranjit,Kavithalakshmi Sataranatarajan,Pavithra Premkumar,Kendra Huseman,Holly Van Remmen,Holly Van Remmen +7 more
TL;DR: In this paper, the activation of Sarcoplasmic Reticulum (SR) Ca2+ ATPase (SERCA) with CDN1163, a novel small molecule allosteric SERCA activator, ameliorates the muscle impairment in the CuZnSOD deficient (Sod1-/-) mouse model of oxidative stress.
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Muscle mitochondrial catalase expression prevents neuromuscular junction disruption, atrophy, and weakness in a mouse model of accelerated sarcopenia
Hongyang Xu,Rojina Ranjit,Arlan Richardson,Arlan Richardson,Holly Van Remmen,Holly Van Remmen +5 more
TL;DR: In this paper, the impact of scavenging muscle mitochondrial hydrogen peroxide on the structure and function of the neuromuscular junction (NMJ) and muscle mass and function in a mouse model of denervation-induced muscle atrophy CuZnSOD (Sod1-/- mice, Sod1KO).
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