Rohit Setlem
University of Texas Southwestern Medical Center
7 Papers
Rohit Setlem is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 1, co-authored 3 publications.
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Papers
Deficiency of PARP-1 and PARP-2 in the mouse uterus results in decidualization failure and pregnancy loss.
Andrew M. Kelleher,Rohit Setlem,Françoise Dantzer,Francesco J. DeMayo,John P. Lydon,W. Lee Kraus +5 more
TL;DR: In this paper, it was shown that PARP-1 and PARP2 ablation in the uterus led to pregnancy loss in mice and increased p53 signaling and an increased population of senescent decidual cells.
29
Transcriptome and proteome dynamics of cervical remodeling in the mouse during pregnancy
Shanmugasundaram Nallasamy,Hector Palacios,Rohit Setlem,Mariano Colon Caraballo,Kelvin W. Li,Edward Cao,Mahalakshmi Shankaran,Marc K. Hellerstein,Mala Mahendroo +8 more
TL;DR: In this paper, the authors explore the transitions in gene expression and protein turnover (fractional synthesis rates [FSR]) by which the cervix implements a transition from rigid to compliant.
20
Functional Characterization of lncRNA152 as an Angiogenesis-Inhibiting Tumor Suppressor in Triple-Negative Breast Cancers
Dae Seok Kim,Shrikanth S. Gadad,Rohit Setlem,Kang Mo Kim,Srinivas Reddy Malladi,Tim Y. Hou,Tulip Nandu,Cristel V. Camacho,W. Lee Kraus +8 more
TL;DR: LncRNA152 may serve as a biomarker to track aggressiveness of breast cancer, as well as therapeutic target for treating TNBC by upregulating the expression of the tumor suppressor RBM47.
6
Oncohistone Mutations Occur at Functional Sites of Regulatory ADP-ribosylation.
Dan Huang,Cristel V. Camacho,Sara Martire,Anusha Nagari,Rohit Setlem,Xuan Gong,Andrea D Edwards,Shu-Ping Chiu,Laura A. Banaszynski,W. Lee Kraus +9 more
TL;DR: Results demonstrate that functional Asp and Glu ADPRylation sites on histones are mutated in cancers, allowing cancer cells to escape the growth-regulating effects of post-translational modifications via distinct mechanisms.
2
Clinical Validation of Tagmentation-Based Genome Sequencing for Germline Disorders.
Heidi Sellers,Maria Angélica C.F. Stein,Pratyush Tandale,Jiayu Tan,Rohit Setlem,Yuta Sakai,Numrah Fadra,Carlos Sosa,Shawn McClelland,Sarah Barnett,Kristen Rasmussen,Cassandra K. Runke,Stephanie A. Smoley,Emma Katzmann,Lori S. Tillmans,Cherisse A. Marcou,Ross A. Rowsey,Erik C. Thorland,Nicole J. Boczek,Hutton M. Kearney,Wei Shen +20 more
TL;DR: In this article , the authors describe clinical validation of tagmentation-based PCR-free GS as a clinical test for rare germline disorders, and demonstrate that while lowering DNA input requirement and reducing library prep time, tagmentationbased WGS enables uniform coverage across the genome and robust detection of various types of genetic alterations.