Roger Ling
University College London
6 Papers
232 Citations
Roger Ling is an academic researcher from University College London. The author has contributed to research in topics: Genotype & Hepatitis E virus. The author has an hindex of 6, co-authored 6 publications.
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Papers
The complete sequence of hepatitis E virus genotype 4 reveals an alternative strategy for translation of open reading frames 2 and 3.
TL;DR: Analysis of the entire sequence confirms the previous conclusion that these Chinese isolates belong to a novel genotype (genotype 4), which is unusual in that a single nucleotide insertion in the ORF 3 region changes the initiation of ORF3, and perhaps also ORF 2.
203
Detection of Sporadic Cases of Hepatitis E Virus (HEV) Infection in China Using Immunoassays Based on Recombinant Open Reading Frame 2 and 3 Polypeptides from HEV Genotype 4
Youchun Wang,Huayuan Zhang,Zhuo Li,Wen-jie Gu,Haiyuan Lan,Wa Hao,Roger Ling,Hemin Li,Tim J. Harrison +8 more
TL;DR: Data indicate that the N terminus of ORF2 may provide epitopes which are highly reactive with acute-phase sera and that assays based on genotypes 1 and 2 alone may be inadequate for the detection of HEV infection in China, where sporadic cases ofHEV infection are caused predominantly by HEV genotypes 4 and 1.
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Unusual hepatitis B surface antigen variation in a child immunised against hepatitis B.
L. Roznovsky,Tim J. Harrison,Zhong-Liao Fang,Roger Ling,I. Lochman,Irena Orságová,Lenka Pliskova +6 more
TL;DR: Perinatal transmission of and infection with hepatitis B (HBV) in early childhood are observed in a small proportion of the offspring of hepatitis B surface antigen (HBsAg)–positive mothers who are vaccinated against HBV immediately after giving birth.
37
Gene expression in HCV-associated hepatocellular carcinoma--upregulation of a gene encoding a protein related to the ubiquitin-conjugating enzyme.
TL;DR: This research aims to investigate gene expression in HCV‐associated human hepatocellular carcinomas by identifying up‐ and down‐regulated genes.
A divergent genotype of hepatitis E virus in Chinese patients with acute hepatitis
Youchun Wang,Roger Ling,James C. Erker,Huayuan Zhang,Hemin Li,Suresh M. Desai,Isa K. Mushahwar,Tim J. Harrison +7 more
TL;DR: A novel variant of HEV, referred to here as the Chinese genotype (genotype 4), may be responsible for a significant proportion of cases of acute hepatitis in China, as seen by the fact that 40% of the HEV-infected patients in this study were genotype 4 positive.