Roger LeGrand
University of Paris-Sud
14 Papers
21 Citations
Roger LeGrand is an academic researcher from University of Paris-Sud. The author has contributed to research in topics: Medicine & Antibody. The author has an hindex of 6, co-authored 9 publications.
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Papers
Patient-derived monoclonal antibody neutralizes SARS-CoV-2 Omicron variants and confers full protection in monkeys
Craig Fenwick,Priscilla Turelli,Dongchun Ni,Laurent Perez,Kelvin Lau,Cecile Herate,Romain Marlin,Erica Lana,Céline Pellaton,Charlène Raclot,Line Esteves-Leuenberger,Jérémy Campos,Alex Farina,Flurin Fiscalini,Nathalie Dereuddre-Bosquet,Francis Relouzat,Rana Abdelnabi,Caroline S. Foo,Johan Neyts,Pieter Leyssen,Yves Levy,Florence Pojer,Henning Stahlberg,Roger LeGrand,Didier Trono,Giuseppe Pantaleo +25 more
TL;DR: In this paper , a mAb named P2G3 was isolated from a previously infected vaccinated donor and showed that it has picomolar-range neutralizing activity against Omicron BA.1.1, BA.2.1 and all other variants tested.
Visualizing the Immune System: Providing Key Insights into HIV/SIV Infections.
TL;DR: Merging imaging platforms with other cutting-edge technologies could lead to novel findings regarding the phenotype, function, and molecular signatures of particular immune cell targets, further promoting the development of new antiviral treatments and vaccination strategies.
A Single-Stranded Oligonucleotide Inhibits Toll-Like Receptor 3 Activation and Reduces Influenza A (H1N1) Infection.
Candice Poux,Aleksandra Dondalska,Joseph Bergenstråhle,Sandra Pålsson,Vanessa Contreras,Claudia Arasa,Peter Järver,Jan Albert,Jan Albert,David C. Busse,Roger LeGrand,Joakim Lundeberg,John S. Tregoning,Anna-Lena Spetz +13 more
TL;DR: Extracellular ssON provides a mechanism for immune regulation of TLR3-mediated responses and suppression of IAV infection in vitro and in vivo in mice and concomitant treatment in mice resulted in maintained weight and reduced viral load in the lungs.
GFP-transduced CD34+ and Lin- CD34- hematopoietic stem cells did not adopt a cardiac phenotype in a nonhuman primate model of myocardial infarct.
Françoise Norol,Nicolas Bonnet,Andre Peinnequin,Fabrice Chretien,Roger LeGrand,Richard Isnard,F. Herodin,Claude Baillou,Benoit Delache,Didier Nègre,David Klatzmann,Jean-Paul Vernant,Francios M. Lemoine +12 more
TL;DR: The data show that GFP(+) CD34(+) and Lin(-)CD34(-)-enriched HSC do not differentiate into cardiomyocytes or into endothelial cells in the infarcted myocardium and that the local production of some growth factors had no positive effect on myocardial regeneration after 3 months.
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Anti-MOG autoantibodies pathogenicity in children and macaques demyelinating diseases
Ché Serguera,Ché Serguera,Ché Serguera,Lev Stimmer,Lev Stimmer,Claire-Maëlle Fovet,Claire-Maëlle Fovet,Philippe Horellou,Vanessa Contreras,Nicolas Tchitchek,Julie Massonneau,Julie Massonneau,Carole Leroy,Audrey Perrin,Julien Flament,Philippe Hantraye,Joanna Demilly,Joanna Demilly,Romain Marignier,Pascale Chrétien,Bert A. 't Hart,Bert A. 't Hart,Jean Boutonnat,Clovis Adam,Roger LeGrand,Kumaran Deiva +25 more
TL;DR: The results support the pertinence of modeling ADS MOG+ in non-human primates to apprehend the natural development of anti-MOG-associated disease, find markers of evolution, and explore the efficacy of targeted therapies to test primate-restricted molecules.